FAM53C and SFN

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		FAM53C	SFN
Description		family with sequence similarity 53 member C	stratifin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Space Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding Protein Kinase C Inhibitor Activity Protein Kinase Binding Identical Protein Binding Cadherin Binding Phosphoprotein Binding
	Biological Process	Protein Import Into Nucleus	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Release Of Cytochrome C From Mitochondria Keratinocyte Development Negative Regulation Of Protein Kinase Activity Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Epidermal Cell Division Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Cell Growth Keratinization Cellular Protein Localization Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Epidermal Cell Differentiation Positive Regulation Of Protein Export From Nucleus Establishment Of Skin Barrier
Pathways			Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Response to radiotherapy in prostate cancer (toxicity, urinary frequency) ( 27515689) Schizophrenia ( 25056061 30285260)	Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Eosinophil percentage of white cells ( 32888494) Neutrophil percentage of granulocytes ( 27863252)
Interacting Genes		6 interacting genes: KDM3B MEOX2 NCK2 SFN SORBS3 YWHAE	56 interacting genes: ABL1 ARAF BAD BAX BCR BRAF CCAR1 CCDC102B CCDC125 CCNH CDC25B CDK1 CHST1 COP1 DUXAP9 EEF1A1 EGFR EIF2S1 EIF4B EXO1 FAM189A2 FAM53C FAM9B FOXO1 FOXO4 GPRIN2 HDAC5 HNRNPD ING1 KCNK15 KCNK3 KCNK9 KIAA0408 LNX2 LONRF1 MAGEA1 MAP3K5 MARK3 MDM4 MKRN3 MST1R NR3C1 NTAQ1 PAX9 PLEKHF2 PLK4 RAB3IP RFFL SAMSN1 TBL3 TP53 TRIM25 TSC2 YWHAG ZC2HC1C ZFP36
Entrez ID		51307	2810
HPRD ID		10785	03185
Ensembl ID		ENSG00000120709	ENSG00000175793
Uniprot IDs		Q9NYF3	P31947
PDB IDs			1YWT 1YZ5 3IQJ 3IQU 3IQV 3LW1 3MHR 3O8I 3P1N 3P1O 3P1P 3P1Q 3P1R 3P1S 3SMK 3SML 3SMM 3SMN 3SMO 3SP5 3SPR 3T0L 3T0M 3U9X 3UX0 4DAT 4DAU 4DHM 4DHN 4DHO 4DHP 4DHQ 4DHR 4DHS 4DHT 4DHU 4FL5 4FR3 4IEA 4JC3 4JDD 4QLI 4Y32 4Y3B 4Y5I 5BTV 5HF3 5LTW 5LU1 5LU2 5MHC 5MOC 5MXO 5MY9 5MYC 5N5R 5N5T 5N5W 5N75 5OEG 5OEH 5OK9 5OKF 5OM0 5OMA 6FAU 6FAV 6FAW 6FBB 6FBW 6FBY 6FCP 6FI4 6FI5 6G6X 6G8I 6G8J 6G8K 6G8L 6G8P 6G8Q 6GHP 6HHP 6HKB 6HKF 6HMT 6HMU 6HN2 6NV2 6QDR 6QDS 6QDT 6QDU 6QHL 6QHM 6QIU 6QZR 6QZS 6R5L 6RHC 6RJL 6RJQ 6RJZ 6RK8 6RKI 6RKK 6RKM 6RL3 6RL4 6RL6 6RM5 6RM7 6RP6 6RWH 6RWI 6RWS 6RWU 6RX2 6S39 6S3C 6S40 6S9Q 6SIN 6SIO 6SIP 6SIQ 6SLV 6SLW 6SLX 6T5F 6T5H 6T80 6TCH 6TJM 6TL3 6TLF 6TLG 6TM7 6TWZ 6W0L 6XWD 6XXC 6XY5 6Y18 6Y1D 6Y1J 6Y3M 6Y3O 6Y3R 6Y3S 6Y3V 6Y3W 6Y40 6Y44 6Y58 6Y8A 6Y8B 6Y8D 6Y8E 6YLU 6YOW 6YOX 6YOY 6YP2 6YP3 6YP8 6YPL 6YPY 6YQ2 6ZCJ 7AEW 7NFW
Enriched GO Terms of Interacting Partners?
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