CYP39A1 and GLUL

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		CYP39A1	GLUL
Description		cytochrome P450 family 39 subfamily A member 1	glutamate-ammonia ligase
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Mitochondrion Rough Endoplasmic Reticulum Cytosol Plasma Membrane Protein-containing Complex Perikaryon Myelin Sheath Axon Terminus Extracellular Exosome Glial Cell Projection
	Molecular Function	Iron Ion Binding Steroid 7-alpha-hydroxylase Activity Steroid Hydroxylase Activity Oxysterol 7-alpha-hydroxylase Activity Heme Binding 24-hydroxycholesterol 7alpha-hydroxylase Activity	Magnesium Ion Binding Glutamate-ammonia Ligase Activity Protein Binding ATP Binding Glutamate Binding Protein-cysteine S-palmitoyltransferase Activity Manganese Ion Binding Identical Protein Binding Dynein Light Chain Binding
	Biological Process	Bile Acid Biosynthetic Process Cholesterol Catabolic Process Digestion Sterol Metabolic Process Cholesterol Homeostasis	Angiogenesis Glutamate Catabolic Process Glutamine Biosynthetic Process Cell Population Proliferation Cellular Response To Starvation Response To Glucose Regulation Of Endothelial Cell Migration Protein Palmitoylation Ammonia Assimilation Cycle Positive Regulation Of Insulin Secretion Ribosome Biogenesis Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Sprouting Angiogenesis Regulation Of Protein Localization To Nucleolus
Pathways		Synthesis of bile acids and bile salts via 24-hydroxycholesterol Endogenous sterols	Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate and glutamine metabolism
Drugs			L-Glutamine Glutamic acid
Diseases
GWAS		Normal facial asymmetry (deformation magnitude) ( 30631343)	Cardiovascular heart disease in diabetics ( 23982368) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol levels ( 32203549) Morning person ( 30696823)
Interacting Genes		4 interacting genes: GLUL ORM2 SERINC1 SMYD3	22 interacting genes: CASP8AP2 CRBN CYP39A1 DYNLL1 EP300 HIPK1 HIPK3 HSD17B10 HTR2A MT-ND5 NFKB1 NUDT18 PIAS1 PIAS2 PIAS3 PLEKHF2 PPARD RABEPK RBBP6 SKIL TAT UBE2I
Entrez ID		51302	2752
HPRD ID		07067	00701
Ensembl ID		ENSG00000146233	ENSG00000135821
Uniprot IDs		A0A087WTD2 B7Z786 Q9NYL5	A8YXX4 P15104
PDB IDs			2OJW 2QC8
Enriched GO Terms of Interacting Partners?
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