BFAR and CASP10

Number of citations of the paper that reports this interaction (PubMedID 10716992)
44

Data Source:
HPRD (in vivo, in vitro)

		BFAR	CASP10
Description		bifunctional apoptosis regulator	caspase 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Integral Component Of Plasma Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane	Cytoplasm Cytosol CD95 Death-inducing Signaling Complex Ripoptosome
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Caspase Binding	Cysteine-type Endopeptidase Activity Protein Binding Ubiquitin Protein Ligase Binding Death Effector Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Negative Regulation Of IRE1-mediated Unfolded Protein Response	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Signaling Pathway Execution Phase Of Apoptosis
Pathways			TP53 Regulates Transcription of Caspase Activators and Caspases FasL/ CD95L signaling TRAIL signaling NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) Basal cell carcinoma ( 25855136) Chronic lymphocytic leukemia ( 28165464 23770605) Chronic lymphocytic leukemia or rheumatoid arthritis ( 31407831) Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		15 interacting genes: BCL2 CASP10 CASP8 CPPED1 PRKACA SHISA9 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2K UBE2N UBE2U UBE2W	36 interacting genes: BFAR BID BMPR2 CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 ERBB4 FADD IGFBP2 NFKBIL1 NPTX1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP SCARB1 TNFRSF1A TRAF1 XIAP YBX3
Entrez ID		51283	843
HPRD ID		16548	03458
Ensembl ID		ENSG00000103429	ENSG00000003400
Uniprot IDs		H3BMP2 Q9NZS9	A0A0S2Z3G5 A0A0S2Z3Z5 Q92851
PDB IDs
Enriched GO Terms of Interacting Partners?
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