PCSK5 and TRIB3

  • Number of citations of the paper that reports this interaction (PubMedID 32296183)
  • 86
  • Data Source:
  • BioGRID (two hybrid)

PCSK5

TRIB3

Description proprotein convertase subtilisin/kexin type 5 tribbles pseudokinase 3
Image No pdb structure No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Alzheimer's disease progression score ( 29860282)
  • Amyotrophic lateral sclerosis (age of onset) ( 22959728)
  • Ankylosing spondylitis ( 30946743)
  • Apolipoprotein B levels ( 32203549)
  • Body fat distribution (leg fat ratio) ( 30664634)
  • Body fat distribution (trunk fat ratio) ( 30664634)
  • Body shape index ( 34021172)
  • Diverticular disease ( 30177863)
  • Glucocorticoid-induced osteonecrosis ( 26265699)
  • Glucose homeostasis traits ( 25524916)
  • Height ( 28552196 20881960 25282103 23563607 31562340)
  • Hip circumference adjusted for BMI ( 34021172)
  • Hypotension and cognitive impairment ( 31362389)
  • Inflammatory bowel disease ( 27569725)
  • Intraocular pressure ( 29785010 31959993 30054594)
  • LDL cholesterol levels ( 32203549)
  • LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • Lead levels ( 26025379)
  • Low density lipoprotein cholesterol levels ( 32154731)
  • Male fertility ( 22633400)
  • Metabolite levels (5-HIAA) ( 23319000)
  • Pursuit maintenance gain ( 29064472)
  • Response to fenofibrate (adiponectin levels) ( 23149075)
  • Schizophrenia, bipolar disorder or major depressive disorder ( 34099189)
  • Systemic sclerosis ( 30247649)
  • Takayasu arteritis ( 25604533)
  • Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
  • Vascular brain injury ( 25188341)
  • Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist circumference adjusted for BMI in non-smokers ( 28443625)
  • Waist circumference adjusted for body mass index ( 34021172 25673412)
  • Waist-hip index ( 34021172)
  • Weight ( 34074324)
  • Information processing speed ( 21130836)
  • Logical memory (delayed recall) ( 29274321)
  • Logical memory (immediate recall) ( 29274321)
Interacting Genes 72 interacting genes: ADAMTSL4 AMH APPBP2 ATN1 C17orf50 C22orf39 CACNA1A CCDC33 CLIC1 CREB5 CYSRT1 DBF4B DEK DOCK2 FAM86C1P FARS2 FRS3 GLRX3 GUCD1 HOXA1 HOXB9 INCA1 ITGA6 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP13-3 KRTAP19-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-9 LCE1D LCE1F LCE2C LCE3C LCE3D MDFI MEOX2 NBPF19 NOTCH2NLA NR1D2 NR4A3 NUFIP2 OTX1 PCSK6 PLSCR4 PMCH POU4F2 PTPRM REN SH3GLB1 SHFL SMCP SPRY1 SSC4D STK16 TEKT4 TLE5 TRAF4 TRIB3 TRIM42 TRIP13 USP54 VGLL3 ZNF547 ZNF655 ZNF837 101 interacting genes: AKAP8L AKT1 AKT2 APOBEC3A APOBEC3C APP ARMC7 ATF4 BAG3 BCL6 BFSP2 BMPR2 C21orf58 C22orf39 CBX8 CHAF1A CLCNKA COPS6 CTAG1A CTAG1B DDIT3 DPPA3 DTX2 EEF1G EFEMP2 EPHB6 EXOSC5 FAAP20 FAM161A FAM90A1 FBXO7 GDF9 GIT1 GLIS3 GPATCH2L GRB2 HAT1 HDAC4 HLA-B HNRNPF HOXB5 HOXC8 IL16 INCA1 INO80B IRX6 KANK2 KAT5 KLHL38 KRT26 LENG1 LMO2 LMO3 MDFI MISP MYC OIP5 OSTF1 PADI4 PARD6B PCSK5 PITX2 PKNOX2 PLCB2 PML PPP1R26 PPP1R32 PRKAB2 PRMT5 PRR19 PSMA3 RARA RBM4 RBM48 RELA RIDA RPGRIP1 RPSA SAMD11 SAXO1 SCNM1 SETDB1 SHFL SNRPC SPAG8 SPG21 SQSTM1 SUOX TCF19 TEKT3 TEKT4 TLE5 TRIM55 TRIM63 TTC23 TWIST1 UBTD2 USP20 UTP23 ZNF417 ZNF587
Entrez ID 5125 57761
HPRD ID 08985 09836
Ensembl ID ENSG00000099139 ENSG00000101255
Uniprot IDs Q92824 B4DMM9 J3KR25 Q96RU7
PDB IDs
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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