ZDHHC2 and MSX2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		ZDHHC2	MSX2
Description		zinc finger DHHC-type palmitoyltransferase 2	msh homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Recycling Endosome Membrane Postsynaptic Recycling Endosome	Chromatin Nucleus Cytosol Nuclear Speck
	Molecular Function	Palmitoyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Protein Homodimerization Activity Protein-cysteine S-stearoyltransferase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Targeting To Membrane Synaptic Vesicle Maturation Peptidyl-L-cysteine S-palmitoylation Protein Palmitoylation Regulation Of Cell-cell Adhesion Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Regulation Of Neuronal Synaptic Plasticity Protein Localization To Plasma Membrane Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Protein Localization To Plasma Membrane Protein Localization To Postsynaptic Membrane Positive Regulation Of AMPA Glutamate Receptor Clustering Positive Regulation Of Endosome To Plasma Membrane Protein Transport	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Cardiac Conduction System Development Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Embryonic Morphogenesis Cranial Suture Morphogenesis Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways		Surfactant metabolism	Regulation of RUNX2 expression and activity
Drugs
Diseases
GWAS		Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Parkinson's disease ( 32201043) Schizophrenia ( 28991256 30285260) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alzheimer's disease ( 33074286) Blond vs. brown/black hair color ( 30531825) Chin dimples ( 27182965) Chronotype ( 30696823) Depressive symptoms (SSRI exposure interaction) ( 25649181) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Red vs. brown/black hair color ( 30531825) Resistant hypertension ( 30237584) Stroke ( 26089329)
Interacting Genes		2 interacting genes: MAFB MSX2	56 interacting genes: ATXN1 CCDC102B CEBPA CLIC3 DLX2 DLX5 EPHB6 FBXW2 FOXH1 GATA2 GTF2F1 GTF2F2 HOXC9 LENG8 MAGED1 MAPK1 MAPK1IP1L MAT2B MGAT5B MSX1 NAF1 NR3C1 PATZ1 PIAS2 PITX1 POLR3D POU1F1 POU2AF1 POU2F2 POU6F2 PPARG PRR13 RBPMS2 RHOXF2 ROR2 RUNX2 SMAP2 SOX5 SPEN TCF7L2 TENT5D TLE1 TLE2 TLE5 TLX3 TOLLIP TSSK3 USP54 VEZF1 XRCC5 XRCC6 YTHDF1 ZBTB17 ZC3H10 ZDHHC2 ZFHX3
Entrez ID		51201	4488
HPRD ID		15715	00421
Ensembl ID		ENSG00000104219	ENSG00000120149
Uniprot IDs		A0A140VKD9 Q9UIJ5	P35548
PDB IDs
Enriched GO Terms of Interacting Partners?
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