ANGPTL4 and FBXW7

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		ANGPTL4	FBXW7
Description		angiopoietin like 4	F-box and WD repeat domain containing 7
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix Blood Microparticle	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol SCF Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
	Molecular Function	Enzyme Inhibitor Activity Signaling Receptor Binding Protein Binding Identical Protein Binding	Protein Binding Cyclin Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Binding Phosphothreonine Residue Binding Ubiquitin-protein Transferase Activator Activity
	Biological Process	Angiogenesis Response To Hypoxia Lipid Metabolic Process Negative Regulation Of Apoptotic Process Protein Unfolding Positive Regulation Of Angiogenesis Negative Regulation Of Lipoprotein Lipase Activity Triglyceride Homeostasis Negative Regulation Of Endothelial Cell Apoptotic Process	Vasculogenesis Vasculature Development Sister Chromatid Cohesion Notch Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Storage Ubiquitin Recycling Protein Ubiquitination Lung Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Destabilization Regulation Of Protein Localization Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Notch Signaling Pathway Rhythmic Process Protein Stabilization Positive Regulation Of Ubiquitin-protein Transferase Activity Lipid Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Osteoclast Development
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes	Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) HDL cholesterol ( 24097068 28270201 24507774 19060906 30275531 25961943 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 33339817) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Metabolite levels (lipoprotein measures) ( 27005778) Myocardial infarction ( 33532862) Phospholipid levels in large HDL ( 29084231) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Total cholesterol levels in HDL ( 29084231) Total triglycerides levels ( 29084231) Triglyceride levels ( 32203549 32154731 33339817 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24507774 30275531 25961943 27036123) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494)
Interacting Genes		9 interacting genes: AURKA BRMS1 CASP8 CDKN2A CDKN2C ESR1 FBXW7 FGFR4 TGFB1	84 interacting genes: ACD AHSG AKT1 ANGPTL4 ANP32B ARL6IP1 BCAS3 BEX1 BLM CCDC6 CCNE1 CCNE2 CDC34 CEBPD CUL1 DISC1 DVL1 EBNA1BP2 EXT1 EZH2 FANCC FBP1 FBP2 FBXO45 GALNT12 GATA2 GATA3 GFI1 GLMN HEMGN HEY1 HIPK2 HNRNPK HRAS IGFBP3 IL24 JUN KLF10 KLF5 KMT2D LINGO1 MAP2K1 MAPK3 MMS22L MYB MYC MYCN NANS NOTCH1 NOTCH4 NPM1 PLK1 PPARGC1A PPP3R2 PRKN PSEN1 PTPN11 RACK1 RFLNA SCGB3A1 SEC61B SHC1 SHOC2 SHPRH SIK2 SKP1 SMAD1 SOX9 SP7 SPI1 SREBF1 STAT3 STAT5A STOML1 STYX SUMF2 TGFB1 TMOD1 TP53 TSC22D4 USP9X WDR97 XPA ZNF510
Entrez ID		51129	55294
HPRD ID		16173	05888
Ensembl ID		ENSG00000167772	ENSG00000109670
Uniprot IDs		Q9BY76	G0Z2K0 Q969H0 S4R3U4
PDB IDs		6EUB 6U0A 6U1U 6U73	2OVP 2OVQ 2OVR 5IBK 5V4B
Enriched GO Terms of Interacting Partners?
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