KMT5B and TSPYL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		KMT5B	TSPYL2
Description		lysine methyltransferase 5B	TSPY like 2
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome, Centromeric Region Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Chromatin Binding Protein Binding Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H4-K20 Specific) Metal Ion Binding S-adenosyl-L-methionine Binding	RDNA Binding Chromatin Binding Protein Binding Histone Binding
	Biological Process	DNA Repair Muscle Organ Development Histone H4-K20 Dimethylation Histone H4-K20 Trimethylation Positive Regulation Of Isotype Switching Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Nucleosome Assembly Cell Cycle Negative Regulation Of DNA Replication Regulation Of Signal Transduction Negative Regulation Of Cell Growth Negative Regulation Of Cell Cycle Regulation Of Protein Kinase Activity
Pathways		PKMTs methylate histone lysines	XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS		Urate levels ( 31578528)
Interacting Genes		4 interacting genes: ESR1 H4C1 SMARCD1 TSPYL2	46 interacting genes: ABT1 AEBP2 APTX CASK CCNB1 CDK1 CDK2 CDK4 CEP19 COIL CREBBP CSNK2A1 EEF1A1 GFI1B H2BC15 HMGXB4 INO80B KMT5B LMO2 LNX1 MCRS1 NOL12 NOP53 PHF19 RBM15 RNF151 RPS25 SIRT6 SNIP1 TBC1D26 TMA16 TNNT1 TSPYL1 XAGE1A XAGE1B ZBTB24 ZBTB48 ZFP1 ZFP91 ZNF280C ZNF286A ZNF329 ZNF524 ZNF687 ZNF775 ZNF835
Entrez ID		51111	64061
HPRD ID		11616	06713
Ensembl ID		ENSG00000110066	ENSG00000184205
Uniprot IDs		B7WNX0 B7Z5N2 Q4FZB7	Q9H2G4
PDB IDs		3S8P 5CPR 5WBV
Enriched GO Terms of Interacting Partners?
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