ZC2HC1A and SP100

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		ZC2HC1A	SP100
Description		zinc finger C2HC-type containing 1A	SP100 nuclear antigen
Image		No pdb structure
GO Annotations	Cellular Component		Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body
	Molecular Function	Protein Binding Metal Ion Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Kinase Binding Protein Domain Specific Binding Identical Protein Binding Protein Dimerization Activity Chromo Shadow Domain Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Regulation Of Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Endothelial Cell Migration Response To Type I Interferon Response To Interferon-gamma Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Maintenance Of Protein Location Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Protein Export From Nucleus Negative Regulation Of Cellular Component Movement Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Fas Signaling Pathway
Pathways			SUMOylation of DNA damage response and repair proteins Interferon gamma signaling
Drugs
Diseases
GWAS		Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 24076602) Neutrophil percentage of white cells ( 32888494) Systemic lupus erythematosus ( 28714469) Weight ( 28552196)	Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Night sleep phenotypes ( 27126917) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		12 interacting genes: APP CASTOR1 CBFA2T2 EGLN3 EXOC8 LASP1 MAPRE3 NCK2 RAD54L2 SP100 WBP4 YES1	39 interacting genes: ACTN2 AMOTL2 ARID3A CASP8AP2 CBX1 CBX3 CBX5 CREBBP CREM DNMT3A DYRK2 ETS1 GIPC2 HEMGN HIPK2 L3MBTL3 LZTR1 MX1 MYB NIPBL PHC1 PML POLR3C RANBP2 RBM39 RTP5 SENP1 SNIP1 SUMO1 SUMO2 SUMO3 TERF1 TERF2 TERF2IP TRAF3IP3 TRIM29 UBE2I USPL1 ZC2HC1A
Entrez ID		51101	6672
HPRD ID		13039	06844
Ensembl ID		ENSG00000104427	ENSG00000067066
Uniprot IDs		B2R9B8 Q96GY0	P23497 Q6ZMK3
PDB IDs			1H5P 4PTB 5FB0 5FB1 5PWE 5PWF 5PWG 5PWH 5PWI 5PWJ 5PWK 5PWL 5PWM 5PWN 5PWO 5PWP 5PWQ 5PWR 5PWS 5PWT 5PWU 5PWV 5PWW 5PWX 5PWY 5PWZ 5PX0 5PX1 5PX2 5PX3 5PX4 5PX5 5PX6 5PX7 5PX8 5PX9 5PXA 5PXB 5PXC 5PXD 5PXE 5PXF 5PXG 5PXH 5PXI 5PXJ 5PXK 5PXL 5PXM 5PXN 5PXO 5PXP 5PXQ 5PXR 5PXS 5PXT 5PXU 5PXV 5PXW 5PXX 5PXY 5PXZ 5PY0 5PY1 5PY2 5PY3 5PY4 5PY5 5PY6 5PY7 5PY8 5PY9 5PYA 5PYB 5PYC 5PYD 5PYE 5PYF 5PYG 5PYH 5PYI 5PYJ 5PYK 5PYL 5PYM 5PYN 5PYO 5PYP 5PYQ 5PYR 5PYS 5PYT 5PYU 5PYV 5PYW 5PYX 5PYY 5PYZ 5PZ0 5PZ1 5PZ2 5PZ3 5PZ4 5PZ5 5PZ6 5PZ7 5PZ8 5PZ9 5PZA 5PZB 5PZC 5PZD 5PZE 5PZF 5PZG 5PZH 5PZI 5PZJ 6G5N 6G5P
Enriched GO Terms of Interacting Partners?
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