DERA and CIT

		DERA	CIT
Description		deoxyribose-phosphate aldolase	citron rho-interacting serine/threonine kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytosol Secretory Granule Lumen Ficolin-1-rich Granule Lumen	Cytoplasm Cytosol Cytoskeleton Membrane
	Molecular Function	Deoxyribose-phosphate Aldolase Activity Protein Binding	Transcription Coactivator Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding SH3 Domain Binding Protein Kinase Binding PDZ Domain Binding Protein Serine/threonine Kinase Inhibitor Activity Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity
	Biological Process	Pentose-phosphate Shunt Deoxyribonucleotide Catabolic Process Carbohydrate Catabolic Process Deoxyribonucleoside Catabolic Process Deoxyribose Phosphate Catabolic Process	Mitotic Cell Cycle Mitotic Cytokinesis Peptidyl-threonine Phosphorylation Actomyosin Structure Organization Positive Regulation Of Cytokinesis Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Catalytic Activity Generation Of Neurons Neuron Apoptotic Process
Pathways		Neutrophil degranulation Pentose phosphate pathway	RHO GTPases activate CIT RHO GTPases activate CIT RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Bone mineral density (hip) and age at menarche ( 26312577) Chronotype ( 30696823) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912)	Mitochondrial heteroplasmy measurement ( 33731350) Number of sexual partners ( 30643258) Urgency urinary incontinence ( 25524241)
Interacting Genes		3 interacting genes: ALDH16A1 CIT HSF2	16 interacting genes: ABCB9 DERA DISC1 DLG4 ENPP7 GRIN1 GRIN2D HIP1R MLXIPL MTNR1A RAC1 RHOA RHOB RHOC RND3 SELPLG
Entrez ID		51071	11113
HPRD ID		13138	09289
Ensembl ID		ENSG00000023697	ENSG00000122966
Uniprot IDs		E9PPM8 Q9Y315	O14578
PDB IDs
Enriched GO Terms of Interacting Partners?
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