ZBTB7B and SH3YL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		ZBTB7B	SH3YL1
Description		zinc finger and BTB domain containing 7B	SH3 and SYLF domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm	Ruffle Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Phosphatase Binding Phosphatidylinositol Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II NK T Cell Differentiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Ectoderm Development Lactation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Histone Deacetylation Positive Regulation Of Interleukin-17 Production Response To Insulin Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of NK T Cell Proliferation Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Adaptive Thermogenesis Negative Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of SREBP Signaling Pathway	Phosphatidylinositol Biosynthetic Process Regulation Of Ruffle Assembly
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Basal cell carcinoma ( 31174203) Bipolar disorder ( 31043756) Birth weight ( 27680694) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807) Body shape index ( 34021172) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Keratinocyte cancer (MTAG) ( 31174203) Multiple sclerosis ( 31604244) Prostate cancer ( 23535732) Refractive error ( 32231278) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 28240269) Blood urea nitrogen levels ( 31152163) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Body shape index ( 34021172) Estimated glomerular filtration rate ( 31152163) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Large artery stroke ( 28265093) Mitochondrial DNA levels ( 25240745) Night sleep phenotypes ( 27126917) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		28 interacting genes: BCL6 BCL6B CCNL2 CRBN EP300 FAM90A1 GRAP2 GRB2 IMP4 KPNA2 MORF4L2 NCK2 NDN OSTF1 P4HA3 PIN1 RELA RPL9 SH3KBP1 SH3YL1 SORBS3 SYTL4 TRIP10 UBTFL1 ZBTB42 ZBTB5 ZNF277 ZSCAN5B	9 interacting genes: AR ERRFI1 GFAP HELZ KHDRBS1 SH3D19 VIM VPS37B ZBTB7B
Entrez ID		51043	26751
HPRD ID		09625	15336
Ensembl ID		ENSG00000160685	ENSG00000035115
Uniprot IDs		O15156	Q96HL8
PDB IDs			2D8H
Enriched GO Terms of Interacting Partners?
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