HDDC2 and POMC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HDDC2	POMC
Description		HD domain containing 2	proopiomelanocortin
Image
GO Annotations	Cellular Component	Cytoplasm	Extracellular Region Extracellular Space Cytoplasm Secretory Granule Secretory Granule Lumen
	Molecular Function	5'-deoxynucleotidase Activity Protein Binding Metal Ion Binding	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Protein Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding
	Biological Process	Dephosphorylation	Generation Of Precursor Metabolites And Energy Signal Transduction Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Calcium-mediated Signaling Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Glucose Homeostasis Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Glycogen Metabolic Process Response To Melanocyte-stimulating Hormone Regulation Of Corticosterone Secretion
Pathways			Opioid Signalling Androgen biosynthesis Glucocorticoid biosynthesis G-protein activation Peptide hormone biosynthesis Endogenous sterols Peptide ligand-binding receptors G alpha (s) signalling events G alpha (i) signalling events Defective ACTH causes obesity and POMCD Interleukin-4 and Interleukin-13 signaling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes ADORA2B mediated anti-inflammatory cytokines production
Drugs			Loperamide Etorphine Dihydromorphine
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hematocrit ( 32888494) Hemoglobin ( 32888494) Midgestational circulating levels of PCBs (fetal genetic effect) ( 28235828) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494)	Body mass index ( 26426971 23669352 20935630) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 28067908) Height ( 28552196 23563607 18391951) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Obesity ( 23563607) Pubertal anthropometrics ( 23449627) Red vs. brown/black hair color ( 30531825) Type 1 diabetes ( 21980299)
Interacting Genes		3 interacting genes: IKBKG LCN2 POMC	28 interacting genes: ABI2 APP ATP6V0D2 BHLHA9 C1orf109 CCDC102B ESRRG FGF10 GLYCTK HDDC2 HLA-DRB3 HSF2BP KLHL42 MC1R MC2R MC3R MC4R MC5R MEP1A MKRN3 NFKBID NRDC NTAQ1 OAZ3 PAM SUOX TXN2 VTN
Entrez ID		51020	5443
HPRD ID		12897	01462
Ensembl ID		ENSG00000111906	ENSG00000115138
Uniprot IDs		A0A140VJK7 Q7Z4H3	P01189
PDB IDs		4DMB 4L1J 4L7E 4L7W	4XNH 4XPD 4Y49 6TUB
Enriched GO Terms of Interacting Partners?
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