ASAP1 and DNAJB6

Number of citations of the paper that reports this interaction (PubMedID 23414517)
13

Data Source:
BioGRID (two hybrid)

		ASAP1	DNAJB6
Description		ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	DnaJ heat shock protein family (Hsp40) member B6
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GO Annotations	Cellular Component	Podosome Cytosol Cell Projection Membrane Dendritic Spine	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Z Disc Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphatidylserine Binding GTPase Activator Activity Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Cadherin Binding Metal Ion Binding	ATPase Activator Activity DNA Binding Protein Binding Heat Shock Protein Binding Protein Folding Chaperone Unfolded Protein Binding Chaperone Binding
	Biological Process	Positive Regulation Of GTPase Activity Cilium Assembly Negative Regulation Of Dendritic Spine Development Positive Regulation Of Podosome Assembly Positive Regulation Of Membrane Tubulation	Protein Folding Actin Cytoskeleton Organization Extracellular Matrix Organization Regulation Of Protein Localization Protein Localization To Nucleus Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intermediate Filament Organization Negative Regulation Of Transcription, DNA-templated Chorio-allantoic Fusion Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Chorion Development Chaperone-mediated Protein Folding Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat
Pathways		VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) HDL cholesterol levels in HIV infection ( 33109212) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494 27863252) Multiple sclerosis ( 19525955) Nevus count or cutaneous melanoma ( 32341527) Platelet count ( 27863252) Platelet distribution width ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Progressive supranuclear palsy ( 30089514) Refractive error ( 32231278) Sleep duration (> 10 hours) ( 33075057) Tuberculosis ( 25774636) Waist circumference adjusted for body mass index ( 28552196)	Body mass index ( 28552196) Retinal detachment or retinal break ( 31816047) Waist circumference ( 28552196)
Interacting Genes		15 interacting genes: ARF1 ARF6 CBL CRK DNAJB6 GRB2 HCK PACSIN3 PTK2 PTK2B PXN RAB11FIP3 REPS2 SH3KBP1 SRC	23 interacting genes: ANKRD1 APP ASAP1 BRMS1 CAND2 DYSF EPHB4 KRT18 MAP3K1 MLF1 MRTO4 MYBPC1 MYOM1 PGM1 PIK3CA POLR1D PTEN SGCG SKAP2 SUPT6H TTN TUBGCP3 USP8
Entrez ID		50807	10049
HPRD ID		05809	07107
Ensembl ID		ENSG00000153317	ENSG00000105993
Uniprot IDs		A0A0A0MRE5 Q9ULH1	A0A0J9YX62 O75190
PDB IDs		2D1X 2DA0 2ED1 2RQT 2RQU	6U3R 6U3S 7JSQ
Enriched GO Terms of Interacting Partners?
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