PAWR and SPSB1

Number of citations of the paper that reports this interaction (PubMedID 20561531)
26

Data Source:
BioGRID (unspecified method)

		PAWR	SPSB1
Description		pro-apoptotic WT1 regulator	splA/ryanodine receptor domain and SOCS box containing 1
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GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Actin Filament Plasma Membrane Actin Cytoskeleton	Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Transcription Corepressor Activity Actin Binding Protein Binding Enzyme Binding Leucine Zipper Domain Binding	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of B Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Fibroblast Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Apoptotic Signaling Pathway Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Cellular Senescence	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Brain morphology (MOSTest) ( 32665545)	Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Body shape index ( 34021172) Cognitive function ( 28093568) Dental caries ( 23064961) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Height ( 28552196 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immune response to anthrax vaccine ( 22658931) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Pulse pressure ( 27841878 30578418) Response to tocilizumab in rheumatoid arthritis ( 22491018) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 27841878 30578418) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		16 interacting genes: AATF ATP5F1C DAPK3 DRD2 HSPA5 PML PRKCZ RRAS2 SLC5A7 SPSB1 SPSB2 SPSB4 SQSTM1 TFPT THAP1 WT1	14 interacting genes: ADPRH ATM DDX4 KDM1A MET NOS2 PAWR PRMT1 PRMT6 RASA1 SUV39H1 TRIM55 TRIM63 VWA5A
Entrez ID		5074	80176
HPRD ID		09051	18106
Ensembl ID		ENSG00000177425	ENSG00000171621
Uniprot IDs		Q96IZ0	A0A024R4G8 Q96BD6
PDB IDs		2JK9	2JK9 3F2O
Enriched GO Terms of Interacting Partners?
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