PAM and UHMK1

Number of citations of the paper that reports this interaction (PubMedID 10574929)
14

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PAM	UHMK1
Description		peptidylglycine alpha-amidating monooxygenase	U2AF homology motif kinase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Trans-Golgi Network Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Transport Vesicle Membrane Secretory Granule Membrane Neuron Projection Perikaryon Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Nucleoplasm Golgi Apparatus Axon Midbody Dendrite Cytoplasm Neuronal Ribonucleoprotein Granule
	Molecular Function	Peptidylglycine Monooxygenase Activity Peptidylamidoglycolate Lyase Activity Copper Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Protein Kinase Binding L-ascorbic Acid Binding Identical Protein Binding	RNA Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transferase Activity Ribonucleoprotein Complex Binding Protein Serine Kinase Activity
	Biological Process	Peptide Amidation Response To Hypoxia Long-chain Fatty Acid Metabolic Process Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Heart Development Lactation Response To PH Toxin Metabolic Process Response To Xenobiotic Stimulus Response To Zinc Ion Protein Amidation Ovulation Cycle Process Response To Estradiol Regulation Of Actin Cytoskeleton Organization Odontogenesis Response To Copper Ion Regulation Of Protein Secretion Response To Glucocorticoid Maternal Process Involved In Female Pregnancy Limb Development Fatty Acid Primary Amide Biosynthetic Process	Peptidyl-serine Phosphorylation Neuron Projection Development Positive Regulation Of Translational Initiation Protein Autophosphorylation Regulation Of Protein Export From Nucleus Regulation Of Cell Cycle
Pathways			Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs		Ascorbic acid N-Alpha-Acetyl-3,5-Diiodotyrosylglycine N-alpha-Acetyl-3,5-diiodotyrosyl-D-threonine
Diseases
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576 29875488) Daytime nap ( 33568662) Diastolic blood pressure ( 29208002) Early cardiac repolarization ( 31600170) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Feeling worry ( 29500382) Insulinogenic index ( 23263489) Medication use (drugs used in diabetes) ( 31015401) Nicotine dependence symptom count ( 25555482) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) PR interval ( 30046033 32439900) Primary biliary cholangitis ( 26394269) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698) Systolic blood pressure ( 29208002) Type 2 diabetes ( 30054458 29358691 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382) Waist-hip index ( 34021172)	Bone mineral density (femoral neck) ( 27424934) Bone mineral density (total hip) ( 27424934) Discordance in emotional problems in monozygotic twins ( 27043157) Takayasu arteritis ( 25604533)
Interacting Genes		10 interacting genes: CALM1 FXYD1 GLP1R KALRN POMC PRKCA RASSF9 TBCA TSC2 UHMK1	9 interacting genes: C1orf109 DEPDC1B LMO1 NDUFAF3 PAM RGS8 STMN1 TMSB4X TSGA10IP
Entrez ID		5066	127933
HPRD ID		01361	12318
Ensembl ID		ENSG00000145730	ENSG00000152332
Uniprot IDs		O43832 P19021	Q8TAS1
PDB IDs
Enriched GO Terms of Interacting Partners?
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