ARHGEF3 and RHOB

Number of citations of the paper that reports this interaction (PubMedID 12221096)
60

Data Source:
HPRD (in vivo)

		ARHGEF3	RHOB
Description		Rho guanine nucleotide exchange factor 3	ras homolog family member B
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Early Endosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Cytoplasmic Vesicle Late Endosome Membrane Cleavage Furrow Cell Projection Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding
	Biological Process	Rho Protein Signal Transduction Positive Regulation Of Rho Protein Signal Transduction Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Mitotic Cytokinesis Angiogenesis Intracellular Protein Transport Apoptotic Process Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity Rho Protein Signal Transduction Endosome To Lysosome Transport Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Cell Migration Cell Differentiation Regulation Of Cell Migration Negative Regulation Of Cell Migration Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Endothelial Tube Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle	GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHOB GTPase cycle
Drugs			Botulinum toxin type A
Diseases
GWAS		Asthma ( 32296059) Attention function in attention deficit hyperactive disorder ( 26174813) Blood protein levels ( 28240269) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Glaucoma (primary open-angle) ( 33627673) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Idiopathic dilated cardiomyopathy ( 29495422) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448) Mean platelet volume ( 22139419 24026423 19110211 19820697 31194788 32888494 27863252 28031487) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Multiple sclerosis ( 31604244) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Obesity-related traits ( 23251661) Platelet count ( 26805783 22139419 24026423 29066854 23263863 29403010 32888494 27863252 28031487) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Refractive error ( 32231278) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Rheumatoid arthritis ( 21452313) Systolic blood pressure ( 30578418)	Systemic sclerosis ( 21750679) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		9 interacting genes: CEP70 HSF2BP PBX4 PICK1 RHOA RHOB TERF1 TRIM23 TRIM27	14 interacting genes: ADORA2A ARHGDIG ARHGEF3 CIT FNTA MAP1A NEDD4L PDE6D PGGT1B PPP2CA RHPN2 SMURF1 SNX17 TNFAIP1
Entrez ID		50650	388
HPRD ID		12480	01321
Ensembl ID		ENSG00000163947	ENSG00000143878
Uniprot IDs		B7Z6B2 E9PG37 Q9NR81	P62745
PDB IDs			2FV8 6HXU 6SGE
Enriched GO Terms of Interacting Partners?
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