P2RY2 and CD47

Number of citations of the paper that reports this interaction (PubMedID 11331301)
51

Data Source:
HPRD (in vivo)

		P2RY2	CD47
Description		purinergic receptor P2Y2	CD47 molecule
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	Protein Binding Signaling Receptor Activity G Protein-coupled Purinergic Nucleotide Receptor Activity	Protein Binding Thrombospondin Receptor Activity Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity
	Biological Process	Cellular Ion Homeostasis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Mucus Secretion Cellular Response To ATP Blood Vessel Diameter Maintenance	Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Cell-cell Adhesion Regulation Of Interferon-gamma Production Regulation Of Interleukin-10 Production Regulation Of Interleukin-12 Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation Positive Regulation Of Stress Fiber Assembly Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Interleukin-12 ATP Export Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Monocyte Extravasation
Pathways		G alpha (q) signalling events P2Y receptors Surfactant metabolism	Cell surface interactions at the vascular wall Integrin cell surface interactions Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation
Drugs		Promethazine Suramin Denufosol INS 316
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Body mass index in asthmatics ( 23517042) Dentures ( 31235808) Glucose homeostasis traits ( 25524916) Insomnia (caffeine-induced) ( 22754043) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Platelet distribution width ( 32888494) Systemic lupus erythematosus ( 26663301) White blood cell count (basophil) ( 27863252)	Bipolar disorder ( 33263727 31043756) Body mass index ( 25673413) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889)
Interacting Genes		7 interacting genes: APP CD47 ITGAV ITGB3 ITGB5 KDR SRC	24 interacting genes: BNIP3 EPB42 FAS GAP43 GNAI1 IGF2BP2 IGSF8 ITGAV MAP3K10 MTIF3 MUC1 P2RY2 PLA1A PTK2 PVR RHAG SIRPA SYNE4 TAGLN3 TFEB THBS1 TMEM167B UBQLN1 ZBTB20
Entrez ID		5029	961
HPRD ID		02499	03017
Ensembl ID		ENSG00000175591	ENSG00000196776
Uniprot IDs		P41231	A0A0A1TSG4 Q08722
PDB IDs		1Z8E	2JJS 2JJT 2VSC 4CMM 4KJY 5IWL 5TZ2 5TZT 5TZU
Enriched GO Terms of Interacting Partners?
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