P2RX4 and DNAAF6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		P2RX4	DNAAF6
Description		purinergic receptor P2X 4	dynein axonemal assembly factor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Nuclear Inner Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Membrane Cell Junction Neuronal Cell Body Terminal Bouton Dendritic Spine Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Trans-Golgi Network
	Molecular Function	Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Cation Channel Activity Signaling Receptor Binding Copper Ion Binding Protein Binding ATP Binding Zinc Ion Binding Identical Protein Binding Cadherin Binding Ligand-gated Calcium Channel Activity	Protein Binding Dynein Intermediate Chain Binding Chaperone Binding
	Biological Process	Tissue Homeostasis Regulation Of Sodium Ion Transport Response To Ischemia Signal Transduction Regulation Of Blood Pressure Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Cardiac Muscle Hypertrophy Neuronal Action Potential Sensory Perception Of Pain Calcium-mediated Signaling Positive Regulation Of Prostaglandin Secretion Response To ATP Ion Transmembrane Transport Response To Fluid Shear Stress Purinergic Nucleotide Receptor Signaling Pathway Endothelial Cell Activation Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Behavioral Response To Pain Response To Axon Injury Positive Regulation Of Calcium-mediated Signaling Regulation Of Chemotaxis Sensory Perception Of Touch Positive Regulation Of Protein Kinase B Signaling Membrane Depolarization Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Relaxation Of Cardiac Muscle Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Cellular Response To Zinc Ion Cellular Response To ATP Apoptotic Signaling Pathway Regulation Of Ruffle Assembly Microglial Cell Migration Positive Regulation Of Microglial Cell Migration Positive Regulation Of Endothelial Cell Chemotaxis	Cilium Movement Flagellated Sperm Motility Outer Dynein Arm Assembly Inner Dynein Arm Assembly Axonemal Dynein Complex Assembly
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis Purinergic signaling in leishmaniasis infection
Drugs		Promethazine Eslicarbazepine acetate Eslicarbazepine
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Left ventricular obstructive tract defect (inherited effect) ( 28468790)
Interacting Genes		10 interacting genes: CDH5 DNAAF6 KRTAP1-1 KRTAP12-3 KRTAP5-9 MCM2 NBPF19 NOTCH2NLA USP16 WNT4	16 interacting genes: ARID4B BTAF1 CCAR1 CDKL3 GAS2L2 KAT5 KIF13A MCM7 P2RX4 PID1 POLDIP2 PRKAA2 QRICH1 RNF39 TSEN15 YAF2
Entrez ID		5025	139212
HPRD ID		09017	06650
Ensembl ID		ENSG00000135124	ENSG00000080572
Uniprot IDs		Q99571	Q9NQM4
PDB IDs
Enriched GO Terms of Interacting Partners?
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