OPRM1 and DOK5

Number of citations of the paper that reports this interaction (PubMedID 23840749)
13

Data Source:
BioGRID (two hybrid)

		OPRM1	DOK5
Description		opioid receptor mu 1	docking protein 5
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Axon Dendrite Dendrite Membrane Dendrite Cytoplasm Sarcolemma Neuron Projection Perikaryon Membrane Raft Spine Apparatus Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Cytoplasm Cytosol
	Molecular Function	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Beta-endorphin Receptor Activity Voltage-gated Calcium Channel Activity Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Filamin Binding G-protein Beta-subunit Binding Morphine Receptor Activity Peptide Binding Neuropeptide Binding
	Biological Process	Acute Inflammatory Response To Antigenic Stimulus G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Sensory Perception Negative Regulation Of Cell Population Proliferation Response To Radiation Sensory Perception Of Pain Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Response To Food Positive Regulation Of Appetite Response To Lipopolysaccharide G Protein-coupled Opioid Receptor Signaling Pathway Wound Healing Response To Cocaine Eating Behavior Estrous Cycle Behavioral Response To Ethanol Positive Regulation Of Neurogenesis Regulation Of Sensory Perception Of Pain Excitatory Postsynaptic Potential Negative Regulation Of Wnt Protein Secretion Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Response To Growth Factor Cellular Response To Morphine Regulation Of Cellular Response To Stress Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of NMDA Receptor Activity	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Differentiation Positive Regulation Of MAPK Cascade Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Pathways		Opioid Signalling G-protein activation Peptide ligand-binding receptors G alpha (i) signalling events Interleukin-4 and Interleukin-13 signaling MECP2 regulates neuronal receptors and channels	RET signaling
Drugs		Tramadol Morphine Codeine Amitriptyline Hydromorphone Methadone Meperidine Oxycodone Levallorphan Dextromethorphan Butorphanol Dextropropoxyphene Pentazocine Naltrexone Sufentanil Alfentanil Fentanyl Loperamide Nalbuphine Levorphanol Remifentanil Ondansetron Anileridine Buprenorphine Hydrocodone Diphenoxylate Naloxone Oxymorphone Dezocine Ketamine Levacetylmethadol Aripiprazole Methadyl acetate 3-Methylthiofentanyl Dimethylthiambutene Diamorphine Ethylmorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl V1003 Epicept NP-1 LI-301 Tapentadol Nalmefene Alvimopan Morphine glucuronide Ketobemidone Methylnaltrexone Naloxegol Cannabidiol Trimebutine Butyrfentanyl Pholcodine Eluxadoline Tianeptine Opium Pentoxyverine Naldemedine Metenkefalin Medical Cannabis Nabiximols Loxicodegol Oliceridine
Diseases
GWAS		Adult body size ( 32376654) Body size at age 10 ( 32376654) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Hypertension ( 21347282) Lipoprotein (a) levels ( 26377243) Menstruation quality of life impact (fever) ( 29855537) Methadone dose in opioid dependence ( 28115739) Nontraumatic osteonecrosis of the femoral head ( 32701715) Opioid use disorder ( 32492095) Type 2 diabetes (age of onset) ( 28060188)	Celiac disease ( 23936387) Erectile dysfunction ( 30583798) Functional MRI ( 20215924) HDL cholesterol levels in HIV infection ( 33109212)
Interacting Genes		78 interacting genes: ADAM33 ADD3 ALOX5AP ATP6V0C ATP6V0E1 C2CD2L CALM1 CCDC167 CD302 CLCN7 CLDN10 CLDN22 CLDN8 CLEC12B CLEC7A CNIH1 COPS5 CPLX1 CTXN3 CYB561 DNAJB4 DOK4 DOK5 DRD2 EHHADH EMP1 EMP3 FLNA GJA4 GNA15 GNAI1 GNAI2 GNAO1 GPRASP1 GRK3 GRM1 HS6ST1 IFITM3 KCNF1 LAT LPAR3 LRRC25 MAL MALL MAP1LC3A MAP1LC3C MFF NELFA NSG1 OPRD1 OPRL1 PLD2 PLD3 PMP22 PPL RPRM RTP4 SCGB1D1 SEC22A SERP2 SIAH1 SIAH2 SLC30A2 SLC38A7 SLC39A13 SLC41A1 SLC9A9 SMAGP TEX264 TM4SF4 TMBIM6 TMEM236 TRARG1 UBC VAPA WLS YIPF3 ZYX	20 interacting genes: AHDC1 ATF3 BNIP3L CCDC85B CDCA4 DOK3 EGFR FANCG IGF1R INSR NTRK2 NTRK3 OLIG1 OPRM1 PFDN5 RAI2 RET SCOC TSC1 WIZ
Entrez ID		4988	55816
HPRD ID		02484	16317
Ensembl ID		ENSG00000112038	ENSG00000101134
Uniprot IDs		B8K2Q5 G8XRH4 G8XRH5 L0E130 P35372	Q9P104
PDB IDs			1J0W
Enriched GO Terms of Interacting Partners?
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