NTRK2 and SORT1

Number of citations of the paper that reports this interaction (PubMedID 21102451)
62

Data Source:
BioGRID (pull down)

		NTRK2	SORT1
Description		neurotrophic receptor tyrosine kinase 2	sortilin 1
Image
GO Annotations	Cellular Component	Early Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Axon Dendrite Early Endosome Membrane Terminal Bouton Dendritic Spine Receptor Complex Axon Terminus Perinuclear Region Of Cytoplasm	Lysosome Lysosomal Membrane Early Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Cell Surface Endosome Membrane Integral Component Of Membrane Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle Dendrite Cytoplasmic Vesicle Nuclear Membrane Golgi Cisterna Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Protease Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Protein Homodimerization Activity Neurotrophin Binding Brain-derived Neurotrophic Factor Binding Brain-derived Neurotrophic Factor-activated Receptor Activity	Protein Binding Nerve Growth Factor Receptor Activity Enzyme Binding Neurotensin Receptor Activity, Non-G Protein-coupled Nerve Growth Factor Binding Retromer Complex Binding
	Biological Process	Vasculogenesis Neuron Migration Positive Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Learning Circadian Rhythm Feeding Behavior Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Glutamate Secretion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Neuronal Action Potential Propagation Central Nervous System Neuron Development Cerebral Cortex Development Myelination In Peripheral Nervous System Neuron Differentiation Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Kinase Activity Neurotrophin Signaling Pathway Mechanoreceptor Differentiation Regulation Of GTPase Activity Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Retinal Rod Cell Development Protein Autophosphorylation Oligodendrocyte Differentiation Peripheral Nervous System Neuron Development Positive Regulation Of Axonogenesis Regulation Of Protein Kinase B Signaling Positive Regulation Of Synapse Assembly Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Amino Acid Stimulus Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Trans-synaptic Signaling By Neuropeptide, Modulating Synaptic Transmission Negative Regulation Of Amyloid-beta Formation Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Brain-derived Neurotrophic Factor Stimulus Negative Regulation Of Anoikis	Ossification Protein Targeting To Lysosome Post-Golgi Vesicle-mediated Transport Golgi To Endosome Transport Endocytosis G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Endosome To Lysosome Transport Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Myotube Differentiation Vesicle Organization Endosome Transport Via Multivesicular Body Sorting Pathway Response To Insulin Nerve Growth Factor Signaling Pathway Negative Regulation Of Fat Cell Differentiation Glucose Import Neurotrophin TRK Receptor Signaling Pathway Plasma Membrane To Endosome Transport Negative Regulation Of Lipoprotein Lipase Activity Golgi To Lysosome Transport Positive Regulation Of Epithelial Cell Apoptotic Process
Pathways		NGF-independant TRKA activation BDNF activates NTRK2 (TRKB) signaling NTF3 activates NTRK2 (TRKB) signaling NTF4 activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FYN NTRK2 activates RAC1 NTRK2 activates RAC1 Activated NTRK2 signals through CDK5	Golgi Associated Vesicle Biogenesis
Drugs		Amitriptyline Esketamine Entrectinib Fostamatinib Larotrectinib
Diseases
GWAS		Birth weight ( 24950379) Body mass index ( 28892062 25760438) Body size at age 10 ( 32376654) Gout (normal type) ( 32238385) Lifetime anxiety disorder ( 31748690) Menarche (age at onset) ( 25231870) Parkinson's disease progression (cognitive) ( 33111402) Refractive error ( 32231278) Serum metabolite concentrations in chronic kidney disease ( 29545352) Type 2 diabetes ( 31118516) Waist-to-hip circumference ratio (recreational physical activity interaction) ( 23192594)	Abdominal aortic aneurysm ( 27899403) Cholesterol, total ( 24097068 25961943 20686565) Chronic kidney disease ( 20383146) Cognitive ability ( 29186694) Coronary artery disease ( 21239051 24262325 26343387 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378988 21378990) Coronary heart disease x type 2 diabetes interaction ( 32541925) HDL cholesterol ( 25961943) LDL cholesterol ( 24097068 18193043 18193044 19060906 19060910 21347282 25961943 20686565) LDL cholesterol levels ( 28334899 26690388) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Low density lipoprotein cholesterol levels ( 30718733 31969989) Low density lipoprotein cholesterol levels (on statin treatment) ( 31969989) Metabolite levels ( 21909109) Metabolite levels (lipoprotein measures) ( 27005778) Myocardial infarction ( 26343387) Myocardial infarction (early onset) ( 19198609) Peripheral artery disease ( 31285632) Progranulin levels ( 21087763 29186428) Ratio of apolipoprotein A1 to apolipoprotein B ( 29084231) Response to statin therapy ( 20339536) Response to statins (LDL cholesterol change) ( 31969989) Response to statins (LDL cholesterol percent change) ( 31969989) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) Total cholesterol levels ( 28334899)
Interacting Genes		38 interacting genes: AP1B1 BDNF CDK20 DOK5 DYNLL1 EGFR ERBB2 ERBB4 FRS2 FRS3 FYN GIPC1 KCNS1 KIDINS220 NCK1 NCK2 NDFIP1 NGFR NMNAT1 NTF3 NTF4 NXNL2 PIK3R1 PLCG1 POLR2G PTPN1 PTPN11 RASGRF1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SORT1 SQSTM1 TRAF6 UBB USP8	17 interacting genes: ADGRG7 BDNF BRICD5 CNIH3 GGA1 GGA2 LRPAP1 NGF NGFR NTF3 NTRK1 NTRK2 NTRK3 NTS SORCS1 SORL1 TF
Entrez ID		4915	6272
HPRD ID		02712	03910
Ensembl ID		ENSG00000148053	ENSG00000134243
Uniprot IDs		A0A024R230 Q16620 Q548C2 Q5VWE5	Q99523
PDB IDs		1HCF 1WWB 2MFQ 4ASZ 4AT3 4AT4 4AT5 5MO9	3F6K 3G2U 3G2V 4MSL 4N7E 4PO7 5MRH 5MRI 6EHO 6X3L 6X48 6X4H
Enriched GO Terms of Interacting Partners?
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