NPPA and NPR2

Number of citations of the paper that reports this interaction (PubMedID 1672777)
90

Data Source:
BioGRID (pull down)

		NPPA	NPR2
Description		natriuretic peptide A	natriuretic peptide receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Brush Border Protein-containing Complex Mast Cell Granule Cell Projection Perikaryon Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Hormone Receptor Binding Neuropeptide Receptor Binding	Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Natriuretic Peptide Receptor Activity Peptide Hormone Binding Hormone Binding Identical Protein Binding
	Biological Process	Response To Hypoxia Negative Regulation Of Systemic Arterial Blood Pressure Cardiac Conduction System Development Aortic Valve Morphogenesis CGMP Biosynthetic Process Protein Folding Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Regulation Of Blood Pressure Positive Regulation Of Heart Rate Positive Regulation Of CGMP-mediated Signaling Cardiac Muscle Hypertrophy In Response To Stress CGMP-mediated Signaling Negative Regulation Of Cell Growth Response To Insulin Response To Muscle Stretch Vasodilation Negative Regulation Of JUN Kinase Activity Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Mechanical Stimulus Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of Histamine Secretion By Mast Cell Positive Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Collecting Lymphatic Vessel Constriction	Ossification CGMP Biosynthetic Process Protein Phosphorylation Signal Transduction Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Blood Pressure Positive Regulation Of CGMP-mediated Signaling CGMP-mediated Signaling Reproductive Process Negative Regulation Of Meiotic Cell Cycle Bone Development Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Oocyte Maturation
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Amyloid fiber formation	Physiological factors
Drugs			Erythrityl tetranitrate Nesiritide
Diseases
GWAS		Atrial fibrillation ( 19597492) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Midregional pro atrial natriuretic peptide levels ( 29237677) Psoriasis ( 25854761) Pulse pressure ( 30578418) Systolic blood pressure ( 19430483 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)	Blood protein levels ( 28240269) Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Height ( 31562340)
Interacting Genes		15 interacting genes: EPB41 ESR1 HNF4A HSF2BP KAZN MAGEA12 MME NPR1 NPR2 NPR3 NR5A2 RORB UBQLN1 UBQLN2 UBQLN4	4 interacting genes: DNAI1 NPPA NPPB NPPC
Entrez ID		4878	4882
HPRD ID		00164	00166
Ensembl ID		ENSG00000175206	ENSG00000159899
Uniprot IDs		P01160	P20594
PDB IDs		1ANP 1YK0 3N57
Enriched GO Terms of Interacting Partners?
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