PNP and NCALD

Number of citations of the paper that reports this interaction (PubMedID 11964161)
23

Data Source:
HPRD (in vivo, in vitro)

		PNP	NCALD
Description		purine nucleoside phosphorylase	neurocalcin delta
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Cytosol Clathrin Coat Of Trans-Golgi Network Vesicle
	Molecular Function	Nucleoside Binding Purine Nucleobase Binding Purine-nucleoside Phosphorylase Activity Protein Binding Phosphate Ion Binding Identical Protein Binding Guanosine Phosphorylase Activity	Actin Binding Calcium Ion Binding Protein Binding Tubulin Binding Clathrin Binding Alpha-tubulin Binding
	Biological Process	Allantoin Metabolic Process Nucleobase-containing Compound Metabolic Process Inosine Catabolic Process Deoxyinosine Catabolic Process Deoxyadenosine Catabolic Process Purine Ribonucleoside Salvage IMP Catabolic Process Nicotinamide Riboside Catabolic Process Immune Response Nucleotide Biosynthetic Process Response To Xenobiotic Stimulus Positive Regulation Of Interleukin-2 Production Urate Biosynthetic Process Positive Regulation Of T Cell Proliferation Purine-containing Compound Salvage DAMP Catabolic Process Positive Regulation Of Alpha-beta T Cell Differentiation	Regulation Of Systemic Arterial Blood Pressure Vesicle-mediated Transport Calcium-mediated Signaling
Pathways		Neutrophil degranulation Purine salvage Purine catabolism	Activation of Ca-permeable Kainate Receptor
Drugs		Cladribine Didanosine 8-azaguanine 2,6-Diamino-(S)-9-[2-(Phosphonomethoxy)Propyl]Purine Immucillin-G Guanine 2-Amino-7-[2-(2-Hydroxy-1-Hydroxymethyl-Ethylamino)-Ethyl]-1,7-Dihydro-Purin-6-One Peldesine 9-deazainosine Guanosine Ribose-1-Phosphate (3R,4R)-3-Hydroxy-4-(hydroxymethyl)-1-[(4-oxo-4,4a,5,7a-tetrahydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]pyrrolidinium 3'-deoxyguanosine (2S,3R,4S,5S)-3,4-Dihydroxy-2-[(methylsulfanyl)methyl]-5-(4-oxo-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)pyrrolidinium Hypoxanthine 9-(5,5-Difluoro-5-Phosphonopentyl)Guanine Inosine 9-DEAZAINOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE GUANOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATE Forodesine
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Aspartate aminotransferase levels ( 33547301 34315874) Blood protein levels ( 30072576) HDL cholesterol levels ( 32203549) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Menopause (age at onset) ( 26414677)	Age-related hearing impairment ( 24939585) Cerebral amyloid angiopathy ( 25188341) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Coffee consumption ( 21876539) Cognitive performance ( 20125193) Coronary artery disease ( 33020668) Gait speed in old age ( 28077804) LDL peak particle diameter (total fat intake interaction) ( 26112879) Medication use (beta blocking agents) ( 31015401) Microalbuminuria ( 26631737) Perceived sweetness of sucrose ( 31005972) Red cell distribution width ( 32888494) Systolic blood pressure ( 30224653)
Interacting Genes		11 interacting genes: APLP1 CCDC90B LRIF1 NCALD NOS1AP RBM48 TFAM TFB2M TP53 UCHL5 ZHX1	33 interacting genes: ACTB ANOS1 APOL3 C19orf44 C1QTNF2 CLTC CREM DTX2 FGF6 FZD7 GOLGA7 GPX7 IGFBP6 KRT6A LCE2D LIF LITAF LY6G6D MEOX2 MICOS10-NBL1 MIEF2 MLLT10 MYDGF NBL1 PLAAT2 PNP SBSN SPRED1 SRGN TMEM14B TPSG1 TUBA4A TUBB
Entrez ID		4860	83988
HPRD ID		01247	09466
Ensembl ID		ENSG00000198805	ENSG00000104490
Uniprot IDs		P00491 V9HWH6	B2RB70 P61601
PDB IDs		1M73 1PF7 1PWY 1RCT 1RFG 1RR6 1RSZ 1RT9 1ULA 1ULB 1V2H 1V3Q 1V41 1V45 1YRY 2A0W 2A0X 2A0Y 2OC4 2OC9 2ON6 2Q7O 3BGS 3D1V 3GB9 3GGS 3INY 3K8O 3K8Q 3PHB 4EAR 4EB8 4ECE 4GKA 5ETJ 5UGF
Enriched GO Terms of Interacting Partners?
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