NEDD4 and PLK2

Number of citations of the paper that reports this interaction (PubMedID 19953087)
57

Data Source:
BioGRID (enzymatic study)

		NEDD4	PLK2
Description		NEDD4 E3 ubiquitin protein ligase	polo like kinase 2
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Chromatin Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Cortex Apicolateral Plasma Membrane Protein-containing Complex Dendritic Spine Perinuclear Region Of Cytoplasm Extracellular Exosome	Chromatin Spindle Pole Nucleus Cytoplasm Centrosome Centriole Cytosol Dendrite
	Molecular Function	Protein Binding Sodium Channel Inhibitor Activity Enzyme Binding Protein Domain Specific Binding Beta-2 Adrenergic Receptor Binding Ubiquitin Binding Phosphoserine Residue Binding Phosphothreonine Residue Binding Ubiquitin Protein Ligase Activity RNA Polymerase Binding Proline-rich Region Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding ATP-dependent Protein Binding Protein-containing Complex Binding Protein Serine Kinase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Lysosome Lysosomal Transport Neuromuscular Junction Development Negative Regulation Of Sodium Ion Transport Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Macroautophagy Protein Ubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Projection Development Receptor Internalization Receptor Catabolic Process Cellular Response To UV Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Glucocorticoid Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Formation Of Structure Involved In A Symbiotic Process Positive Regulation Of Protein Catabolic Process Viral Budding Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Progesterone Receptor Signaling Pathway Response To Calcium Ion Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Sodium Ion Transmembrane Transporter Activity	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Mitotic Spindle Organization Ras Protein Signal Transduction Memory Positive Regulation Of Autophagy Negative Regulation Of Angiogenesis Peptidyl-serine Phosphorylation Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Rap Protein Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Catabolic Process Regulation Of Centriole Replication Regulation Of Synaptic Plasticity Long-term Synaptic Potentiation Long-term Synaptic Depression Negative Regulation Of Dendritic Spine Development Negative Regulation Of Apoptotic Process In Bone Marrow Cell Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cellular Senescence
Pathways		ISG15 antiviral mechanism Downregulation of ERBB4 signaling Regulation of PTEN localization Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CD163 mediating an anti-inflammatory response
Drugs			Fostamatinib
Diseases
GWAS		Brain connectivity ( 23471985) Chronic lymphocytic leukemia ( 28165464 24292274) Dupuytren's disease ( 28886342) Hip circumference adjusted for BMI ( 28552196) Intraocular pressure ( 29617998) Joint mobility (Beighton score) ( 27182965) Keloid ( 20711176) Refractive error ( 32231278) Stroke ( 29531354)	Blond vs. brown/black hair color ( 30531825) Diastolic blood pressure ( 30224653) Esophageal adenocarcinoma x smoking interaction ( 29551738) Multisite chronic pain ( 33830993) Triglyceride levels ( 32203549) Type 2 diabetes (age of onset) ( 28060188) Working memory ( 31598132)
Interacting Genes		242 interacting genes: ABCB1 ABL1 ABL2 ADRB2 AKT1 AKT3 AMOT AMOTL1 AMPD2 ANKRD13D ANXA13 AP1G2 ARID1A ASPSCR1 AURKC BAIAP2 BMPR1A BRCA2 CAD CALCOCO1 CAMK1D CAMK4 CAMKK2 CASP1 CASP3 CASP6 CASP7 CBLB CCNH CDC25C CDK5 CDK5R1 CLIC2 CLK3 CPSF1 CPSF6 CUEDC1 DAZAP2 DCUN1D1 DDX3X DDX54 DHX30 DIAPH1 DVL1 DYRK4 EBAG9 EGFR EPHA5 EPRS1 EPS15 ERBB3 ERBB4 ERMN ERRFI1 FES FGF12 FGF21 FGFR1 FGFR2 FKBP3 FLT1 FLT4 FYN GABARAP GABARAPL1 GABARAPL2 GBA GFUS GRB10 GRIN2A GRK4 GRK7 H3-3A HGS HMCES HNRNPK HNRNPL HNRNPU HNRNPUL1 IFITM3 IGF1R IL1B IRS1 IRS2 JHY JUN KCNAB1 KCNAB2 KCNJ16 KIFC3 LAPTM5 LATS1 LINC01198 LITAF LUC7L2 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K2 MAP3K3 MAP3K5 MAP4K5 MAPKAPK3 MARK2 MARK4 MLANA MOB3A MRPL19 MTMR4 MYCN MYO15B N4BP2 N4BP3 NDFIP1 NDFIP2 NFE2 NHP2 NSRP1 NUDT21 NUMB PARP16 PAX7 PDGFRB PIP5K1A PIP5K1C PKN2 PLK1 PLK2 PMEPA1 POLR1C POLR2A POLR2B POLR2C POLR2E POLR2M POLR3A PRKG2 PRKX PRPF8 PRR16 PRRG1 PRRG2 PSMD4 PTEN PYM1 RAC1 RAD51AP1 RAF1 RANBP10 RAP2A RAPGEF2 RAPGEF6 RASGEF1A RASL11B RBCK1 RET RFT1 RNF11 RNF7 RPAP2 RPAP3 RPL18A RPS3A RPS6KA3 RPS6KA4 RPS6KB1 RUNX1 RUVBL1 SAAL1 SAMSN1 SAV1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SEPTIN9 SERTAD1 SFTPC SGK1 SGK2 SH3KBP1 SHISA6 SHTN1 SIVA1 SLC23A2 SLC6A3 SMAD1 SMAD3 SMAD5 SMARCC1 SMO SNCA SP140L SPANXN3 SPRY2 SQSTM1 SRC SRMS SRSF7 STK24 STK25 STK26 STK31 STK4 SULF1 SYK SYT1 TAF1B TBC1D7 TBK1 TCEANC TCP11L1 TEAD2 THOC1 THRAP3 TNIK TOM1 TOM1L2 TP53BP2 TP73 TRIM44 TRIM52 TRPV6 TTYH2 UBAP2L UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L3 UBE2M UBOX5 URI1 VDAC2 VDAC3 WBP1 WBP2 WEE1 YES1 YOD1	10 interacting genes: APP CASK CDC20B CENPU CIB1 MPP3 NEDD4 SNCA TSC1 TSC2
Entrez ID		4734	10769
HPRD ID		03786	06118
Ensembl ID		ENSG00000069869	ENSG00000145632
Uniprot IDs		P46934	A0A024QZV1 A0A087WUH9 Q9NYY3
PDB IDs		2KPZ 2KQ0 2M3O 2XBB 2XBF 3B7Y 4BBN 4BE8 4N7F 4N7H 5AHT 5C7J 5C91	4I5M 4I5P 4I6B 4I6F 4I6H 4RS6 4XB0
Enriched GO Terms of Interacting Partners?
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