NAB2 and APH1B

		NAB2	APH1B
Description		NGFI-A binding protein 2	aph-1 homolog B, gamma-secretase subunit
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Endoplasmic Reticulum Plasma Membrane Endosome Membrane Integral Component Of Membrane Transport Vesicle Gamma-secretase Complex
	Molecular Function	Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Identical Protein Binding	Protein Binding Protein-macromolecule Adaptor Activity Endopeptidase Activator Activity
	Biological Process	Endochondral Ossification Regulation Of Transcription, DNA-templated Schwann Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase III Myelination Regulation Of Epidermis Development Positive Regulation Of Tau-protein Kinase Activity	Notch Signaling Pathway Notch Receptor Processing Locomotory Behavior Positive Regulation Of Endopeptidase Activity Protein Processing Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process
Pathways		NGF-stimulated transcription NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination	Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31361310 31959851 31619474 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) IgE levels ( 22075330) Schizophrenia ( 25056061 29483656)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Estimated glomerular filtration rate ( 31152163) Family history of Alzheimer's disease ( 30617256) Metabolite levels ( 23823483) Myopia ( 27182965) Refractive error ( 32231278) Response to fenofibrate (triglyceride levels) ( 27002377) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		87 interacting genes: ANK3 ANKRD11 APH1B CBX8 CCDC187 CCDC33 CCDC57 CCHCR1 CDC23 CTAG1A CTAG1B CTNNA3 CWF19L2 DDX6 DGCR6 DGCR6L DRG2 EGR1 EGR2 ELOA ENKD1 EXOC8 FAM9A GCC1 GOLGA6L9 HOXA10 HRH1 HSF2BP JAKMIP2 KIF9 KIFC3 KRT34 KRT40 KRTAP10-3 KRTAP10-8 LENG1 LMNA LNX1 LRP1 MAPK3 MCM7 MCRS1 MDFI MORF4L1 MORF4L2 MYO1A NDOR1 NEDD9 NME7 NOTCH2NLA NTAQ1 PHF1 PHOSPHO2 PIK3R3 PIN1 PLOD3 PRKAA2 PRKAB2 PSMA1 QARS1 RBPMS RDH5 RFC5 RINT1 SCN1A SCNM1 SMARCD1 SORBS3 SPG21 SUMO1P1 TCEA2 TCEANC TCHP TGIF2LY TLE5 TRAF2 TRIM23 TSGA10 TSGA10IP TTC19 USP2 UTP14C ZBED8 ZMAT2 ZMYND12 ZMYND19 ZNF417	8 interacting genes: FXYD6-FXYD2 NAB2 NCSTN PSEN1 PSEN2 TM4SF4 TRARG1 VSTM1
Entrez ID		4665	83464
HPRD ID		03854	06361
Ensembl ID		ENSG00000166886	ENSG00000138613
Uniprot IDs		Q15742	Q8WW43
PDB IDs
Enriched GO Terms of Interacting Partners?
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