MYOC and TKT

Number of citations of the paper that reports this interaction (PubMedID 16289162)
27

Data Source:
BioGRID (far western blotting)
HPRD (in vitro)

		MYOC	TKT
Description		myocilin	transketolase
Image
GO Annotations	Cellular Component	Extracellular Space Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Cytoplasmic Vesicle Node Of Ranvier Collagen-containing Extracellular Matrix Extracellular Exosome	Nucleoplasm Peroxisome Endoplasmic Reticulum Membrane Cytosol Nuclear Body Vesicle Extracellular Exosome
	Molecular Function	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding Metal Ion Binding	Magnesium Ion Binding Transketolase Activity Calcium Ion Binding Protein Binding Thiamine Pyrophosphate Binding Protein Homodimerization Activity
	Biological Process	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway Via JNK Cascade ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Pentose-phosphate Shunt Pentose-phosphate Shunt, Non-oxidative Branch Regulation Of Growth Glyceraldehyde-3-phosphate Biosynthetic Process Ribose Phosphate Biosynthetic Process
Pathways			Insulin effects increased synthesis of Xylulose-5-Phosphate Pentose phosphate pathway
Drugs			Copper
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Glaucoma ( 30104761) Glaucoma (primary open-angle) ( 33627673) Intake of total sugars ( 31005972)	Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Body mass index ( 26426971) Body shape index ( 34021172) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) QRS duration ( 27577874 30012220 27659466) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		41 interacting genes: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 SGTA TGFBR1 TIMP1 TKT TNFRSF1A	6 interacting genes: ITGB1BP2 LINC01554 MYOC SERPINB5 SQSTM1 TERF1
Entrez ID		4653	7086
HPRD ID		03387	06001
Ensembl ID		ENSG00000034971	ENSG00000163931
Uniprot IDs		A0A0S2Z421 Q99972	A0A0B4J1R6 P29401 V9HWD9
PDB IDs		4WXQ 4WXS 4WXU 6OU0 6OU1 6OU2 6OU3 6PKD 6PKE 6PKF	3MOS 3OOY 4KXU 4KXV 4KXW 4KXX 4KXY 6HA3 6HAD 6RJB
Enriched GO Terms of Interacting Partners?
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