MYO10 and ITGB5

Number of citations of the paper that reports this interaction (PubMedID 15156152)
138

Data Source:
HPRD (two hybrid, in vivo)

		MYO10	ITGB5
Description		myosin X	integrin subunit beta 5
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleolus Cytosol Plasma Membrane Cell Cortex Myosin Complex Lamellipodium Filopodium Membrane Filopodium Tip Neuron Projection Neuronal Cell Body	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Integrin Alphav-beta5 Complex Receptor Complex Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Microfilament Motor Activity Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Spectrin Binding Actin Filament Binding Plus-end Directed Microfilament Motor Activity	Virus Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity
	Biological Process	Signal Transduction Regulation Of Cell Shape Positive Regulation Of Cell-cell Adhesion Cytoskeleton-dependent Intracellular Transport Regulation Of Filopodium Assembly	Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell Migration Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Stress Fiber Assembly Viral Entry Into Host Cell Epithelial Cell-cell Adhesion
Pathways		Regulation of actin dynamics for phagocytic cup formation Netrin-1 signaling FCGR3A-mediated phagocytosis	Cross-presentation of particulate exogenous antigens (phagosomes) Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions Syndecan interactions Syndecan interactions ECM proteoglycans Smooth Muscle Contraction
Drugs
Diseases
GWAS		Body mass index (change over time) in lung cancer or chronic obstructive pulmonary disease ( 28044437) Circulating odd-numbered chain saturated fatty acid levels (C17:0) ( 29738550) Major depressive disorder ( 23377640) Metabolite levels ( 23823483) Normal facial asymmetry (deformation magnitude) ( 30631343) Obesity-related traits ( 23251661) Response to antidepressants (symptom remission) ( 29160301) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Airway hyperresponsiveness ( 23984888) Carpal tunnel syndrome ( 30833571) Coronary artery disease ( 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin concentration ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		7 interacting genes: ACTA1 CALM1 CALML3 DNAH5 DYNLL1 ITGB5 PLA2G10	58 interacting genes: ANXA5 APPBP2 CCN1 CYSRT1 DAB1 DAB2 DOK1 EFEMP2 EHMT2 EPS8 EWSR1 FDFT1 FHL2 FHL3 FLNA GAPDH GOLGA2 GON4L ITGA5 ITGAV ITGB3BP KRT31 KRT34 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-2 KRTAP5-7 LTBP1 LTBP3 MTDH MTUS2 MYBPC2 MYO10 NBPF19 NOTCH2NLA NUMB P2RY2 PAK4 PALLD PPARD PTK2 RACK1 SNTA1 SPP1 SRSF9 STAB2 TAF1 TLN1 TNS2 TRIM55 TRIM63 TTN ZBTB17 ZNF655
Entrez ID		4651	3693
HPRD ID		03283	00949
Ensembl ID		ENSG00000145555	ENSG00000082781
Uniprot IDs		Q9HD67	D3DNA1 L7RT22 P18084
PDB IDs		2LW9 3AU4 3AU5 3PZD 5I0H 5I0I 5KG8
Enriched GO Terms of Interacting Partners?
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