MTAP and CENPH

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		MTAP	CENPH
Description		methylthioadenosine phosphorylase	centromere protein H
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Extracellular Exosome	Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytosol
	Molecular Function	1,4-alpha-oligoglucan Phosphorylase Activity Protein Binding S-methyl-5-thioadenosine Phosphorylase Activity	Protein Binding Kinetochore Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Purine Ribonucleoside Salvage Nicotinamide Riboside Catabolic Process L-methionine Salvage From Methylthioadenosine Methylation Response To Testosterone	Mitotic Spindle Organization Chromosome Segregation Kinetochore Assembly Kinetochore Organization
Pathways		Methionine salvage pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Adenine (2S,3S,4R,5S)-2-(4-Amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(methylsulfanyl)methyl]-3,4-pyrrolidinediol Formycin 5'-S-methyl-5'-thioadenosine 5'-Deoxy-5'-(Methylthio)-Tubercidin
Diseases
GWAS		Adverse response to drug ( 30420678) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary heart disease ( 21606135) Cutaneous malignant melanoma ( 32341527) Cutaneous nevi ( 19578365) Diastolic blood pressure ( 28135244) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Glycated hemoglobin levels ( 28898252) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in never smokers ( 28604730) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Macular thickness ( 30535121) Mean spheric corpuscular volume ( 32888494) Melanoma ( 21983787 28212542) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 32341527 30429480) Pediatric bone mineral content (radius) ( 26041818) Pulse pressure ( 28135244)
Interacting Genes		9 interacting genes: CDC25A CENPH EMC3 FOLH1 LYRM1 MYLIP PKD2 PLCB2 RELB	18 interacting genes: ABI2 C1orf216 C8orf58 CCDC146 DCTN2 ERH H2AP KIF2C LMNB1 MESD MTAP NDC80 NUF2 NUP54 RASSF4 SPAG5 ZNF493 ZSCAN12
Entrez ID		4507	64946
HPRD ID		01134	12029
Ensembl ID		ENSG00000099810	ENSG00000153044
Uniprot IDs		A0A384ME80 Q13126	A0A0S2Z5T0 Q9H3R5
PDB IDs		1CB0 1CG6 1K27 1SD1 1SD2 3LN5 3OZC 3OZD 3OZE 5EUB 5TC5 5TC6 5TC7 5TC8 6DYZ 6DZ0 6DZ2 6DZ3
Enriched GO Terms of Interacting Partners?
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