MST1 and MST1R

Number of citations of the paper that reports this interaction (PubMedID 9045873)
20

Data Source:
HPRD (in vivo)

		MST1	MST1R
Description		macrophage stimulating 1	macrophage stimulating 1 receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix	Stress Fiber Vacuole Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Cell Surface Receptor Complex
	Molecular Function	Endopeptidase Activity Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Macrophage Colony-stimulating Factor Receptor Activity Protein Binding ATP Binding Enzyme Binding
	Biological Process	Proteolysis Histone H2A-S139 Phosphorylation Negative Regulation Of Gluconeogenesis Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of CAMP-dependent Protein Kinase Activity	Phagocytosis Defense Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Single Fertilization Nervous System Development Positive Regulation Of Cell Population Proliferation Response To Virus Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Protein Kinase B Signaling
Pathways		Signaling by MST1	Signaling by MST1
Drugs			Fostamatinib
Diseases
GWAS		Blood protein levels ( 29875488 28240269) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 18587394 28067908 17554261 17554300 21102463) Extremely high intelligence ( 29520040) Feeling miserable ( 29500382) Inflammatory bowel disease ( 28067908 23128233) Primary sclerosing cholangitis ( 23603763 27992413 21151127) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 19915572 28067908 20228799 25082827 21297633)	Adult body size ( 32376654) Age at first birth ( 27798627) Body mass index ( 26426971 29273807) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Inflammatory bowel disease ( 23128233) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 25082827) Walking pace ( 33128006)
Interacting Genes		10 interacting genes: BECN1 FOXO1 KLKB1 MOB1A MST1R RASSF1 SERPINA3 TNNC1 TNNI3 TNNT2	25 interacting genes: AKT1 EPOR ERBB2 GAB1 GJB1 GPX1 GRB2 HYAL2 JAK2 MST1 PIK3R1 PLCG1 PPP1CA PTPRR RELA SFN SHC1 SRC STUB1 YES1 YWHAB YWHAE YWHAH YWHAQ YWHAZ
Entrez ID		4485	4486
HPRD ID		00798	02545
Ensembl ID		ENSG00000173531	ENSG00000164078
Uniprot IDs		G3XAK1 P26927 Q53GN8	B4E058 G9JXB8 Q04912
PDB IDs		2ASU 4QT8	3PLS 4FWW 4QT8
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?