MSH5 and NEU1

		MSH5	NEU1
Description		mutS homolog 5	neuraminidase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome	Extracellular Region Cytoplasm Lysosome Lysosomal Membrane Plasma Membrane Membrane Cell Junction Specific Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Mismatched DNA Binding	Exo-alpha-sialidase Activity Protein Binding Alpha-sialidase Activity Exo-alpha-(2->3)-sialidase Activity Exo-alpha-(2->6)-sialidase Activity Exo-alpha-(2->8)-sialidase Activity
	Biological Process	Meiotic Mismatch Repair Reciprocal Meiotic Recombination	Ganglioside Catabolic Process Oligosaccharide Catabolic Process
Pathways		Meiotic recombination	Glycosphingolipid metabolism Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation
Drugs			Oseltamivir
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 28240269) Body shape index ( 34021172) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Cutaneous lupus erythematosus ( 25827949) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Lung cancer ( 18978787) Mastocytosis ( 32752121) Medication use (anilides) ( 31015401) Menopause (age at onset) ( 26414677) Pulse pressure ( 27618448) Systemic lupus erythematosus ( 26316170) Systemic mastocytosis ( 32752121) Systolic blood pressure ( 27618448) Takayasu arteritis ( 25604533) Ulcerative colitis ( 24837172 28067908)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Basal cell carcinoma ( 27539887) Blood protein levels ( 28240269) Body shape index ( 34021172) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Small cell lung carcinoma ( 28604730) Squamous cell lung carcinoma ( 28604730) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172)
Interacting Genes		6 interacting genes: MLH1 MLH3 MSH4 NEU1 NOTCH4 TRIM54	37 interacting genes: AQP6 CCR9 CD79A CDC42SE2 CERS3 CERS4 CREB3 CREB3L1 CTSA EBP EEF1A1 ERGIC3 ERRFI1 GLB1 GOLM1 GPR152 GPX8 HSD17B11 IGF1 JUNB KCNA2 KCNA4 LIG4 LMNA MAF MGST3 MSH5 MUC1 NFYA NOTCH4 PBX2 SLC10A1 SLC10A6 SLC17A2 SLC18A1 SLC39A9 TMEM14B
Entrez ID		4439	4758
HPRD ID		04544	09751
Ensembl ID		ENSG00000204410	ENSG00000204386
Uniprot IDs		A0A024RCM1 A0A024RCV6 O43196	Q5JQI0 Q99519
PDB IDs
Enriched GO Terms of Interacting Partners?
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