ABCC1 and TNFRSF17

		ABCC1	TNFRSF17
Description		ATP binding cassette subfamily C member 1	TNF receptor superfamily member 17
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Extracellular Exosome	Plasma Membrane Endomembrane System Integral Component Of Membrane
	Molecular Function	ATP Binding ABC-type Xenobiotic Transporter Activity ABC-type Vitamin B12 Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity Efflux Transmembrane Transporter Activity Hydrolase Activity ATPase-coupled Lipid Transmembrane Transporter Activity Glutathione Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Carboxylic Acid Transmembrane Transporter Activity ABC-type Transporter Activity	Protein Binding Signaling Receptor Activity
	Biological Process	Leukotriene Metabolic Process Cobalamin Metabolic Process Response To Xenobiotic Stimulus Inorganic Anion Transport Cobalamin Transport Cellular Response To Oxidative Stress Glutathione Transmembrane Transport Heme Catabolic Process Xenobiotic Transport Phospholipid Translocation Positive Regulation Of Inflammatory Response Transmembrane Transport Cell Chemotaxis Transepithelial Transport Leukotriene Transport Sphingolipid Translocation Export Across Plasma Membrane Transport Across Blood-brain Barrier Cellular Response To Amyloid-beta Carboxylic Acid Transmembrane Transport Xenobiotic Transport Across Blood-brain Barrier	Adaptive Immune Response Lymphocyte Homeostasis Signal Transduction Multicellular Organism Development Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		Heme degradation Cobalamin (Cbl, vitamin B12) transport and metabolism Synthesis of Leukotrienes (LT) and Eoxins (EX) ABC-family proteins mediated transport Cytoprotection by HMOX1	TNFs bind their physiological receptors
Drugs		ATP Sulfinpyrazone Biricodar Romidepsin Leukotriene C4	Belantamab mafodotin
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Estimated glomerular filtration rate ( 31152163) Hip circumference adjusted for BMI ( 34021172) Ischemic stroke (undetermined subtype) ( 26708676) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple myeloma (survival) ( 26198393) Pelvic organ prolapse (moderate/severe) ( 26545240) Psychosis proneness (perceptual aberration scale) ( 28525603) Rate of ventricular enlargement ( 31711042) Red cell distribution width ( 32888494) Response to antiepileptic mood-stabilizing treatment in bipolar disorder ( 32627186) Serum metabolite levels ( 33031748) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) White blood cell count (basophil) ( 27863252)	Blood protein levels ( 30072576) Phenylephrine infusion rate during anesthesia ( 31455332) QT interval ( 19305408) Testicular germ cell tumor ( 26503584)
Interacting Genes		7 interacting genes: ATP5F1A AZGP1 CSNK2A1 NPM1 NR3C1 TNFRSF17 TRAF3	9 interacting genes: ABCC1 CMTM7 PEX16 TMBIM6 TNFSF13 TNFSF13B TRAF1 TRAF2 TRAF3
Entrez ID		4363	608
HPRD ID		01153	00144
Ensembl ID		ENSG00000103222	ENSG00000048462
Uniprot IDs		P33527	Q02223
PDB IDs		2CBZ 4C3Z	1OQD 1XU2 2KN1 4ZFO 6J7W
Enriched GO Terms of Interacting Partners?
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