MRE11 and LIG1

Number of citations of the paper that reports this interaction (PubMedID 8530104)
36

Data Source:
HPRD (two hybrid)

		MRE11	LIG1
Description		MRE11 homolog, double strand break repair nuclease	DNA ligase 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Cytosol PML Body Mre11 Complex Site Of Double-strand Break	Nucleus Nucleoplasm Cytoplasm Mitochondrion Intracellular Membrane-bounded Organelle
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding DNA Helicase Activity Double-stranded DNA Binding Nuclease Activity Endodeoxyribonuclease Activity Protein Binding Protein C-terminus Binding 3'-5'-exodeoxyribonuclease Activity 3'-5' Exonuclease Activity 5'-3' Exonuclease Activity Manganese Ion Binding Identical Protein Binding Cadherin Binding	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity ATP Binding Metal Ion Binding
	Biological Process	Regulation Of Mitotic Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomerase Sister Chromatid Cohesion Mitotic G2 DNA Damage Checkpoint Signaling Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Cell Population Proliferation Mitotic Intra-S DNA Damage Checkpoint Signaling Telomeric 3' Overhang Formation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Telomere Maintenance DNA Duplex Unwinding Positive Regulation Of Kinase Activity Meiotic DNA Double-strand Break Formation Negative Regulation Of Apoptotic Process Mitochondrial Double-strand Break Repair Via Homologous Recombination DNA Strand Resection Involved In Replication Fork Processing	DNA Ligation Lagging Strand Elongation DNA Repair Base-excision Repair Base-excision Repair, Gap-filling Mismatch Repair Anatomical Structure Morphogenesis V(D)J Recombination Cell Division DNA Biosynthetic Process Okazaki Fragment Processing Involved In Mitotic DNA Replication
Pathways		Cytosolic sensors of pathogen-associated DNA DNA Damage/Telomere Stress Induced Senescence IRF3-mediated induction of type I IFN HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	POLB-Dependent Long Patch Base Excision Repair Early Phase of HIV Life Cycle Processive synthesis on the C-strand of the telomere Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER Processive synthesis on the lagging strand
Drugs			Bleomycin
Diseases
GWAS
Interacting Genes		29 interacting genes: - ATM ATR CCNE1 CDK2 CXCR5 DCLRE1C DYNC1H1 DYNLL1 ENDOD1 EP300 FANCD2 GPR83 H2AX H4C1 JRKL LIG1 MAPK8IP2 MLF2 NBN NEK1 PRKDC RAD50 RECQL5 SPOP SUMO1 SUMO2 TMEM126A XRCC6	19 interacting genes: CBX3 CDY1 CDYL CDYL2 CSNK2A1 DCAF7 EHMT1 EHMT2 HSPB1 INPP1 L3MBTL3 MIER1 MRE11 PCNA PHF20 PRKCB RGS2 TUBB3 UHRF1
Entrez ID		4361	3978
HPRD ID		02889	00534
Ensembl ID		ENSG00000020922	ENSG00000105486
Uniprot IDs		A0A024R395 F8W7U8 P49959 Q05D78	B4DM52 F5GZ28 P18858
PDB IDs		3T1I	1X9N 5YY9 6P09 6P0A 6P0B 6P0C 6P0D 6P0E 6Q1V 7KR3 7KR4 7L34 7L35
Enriched GO Terms of Interacting Partners?
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