ALDH6A1 and CHRNA5

		ALDH6A1	CHRNA5
Description		aldehyde dehydrogenase 6 family member A1	cholinergic receptor nicotinic alpha 5 subunit
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Neuron Projection Synapse Postsynaptic Membrane Dopaminergic Synapse
	Molecular Function	Fatty-acyl-CoA Binding RNA Binding Methylmalonate-semialdehyde Dehydrogenase (acylating) Activity Malonate-semialdehyde Dehydrogenase (acetylating) Activity Malonate-semialdehyde Dehydrogenase (acetylating, NAD+) Activity	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity
	Biological Process	Thymine Catabolic Process Valine Metabolic Process Valine Catabolic Process Branched-chain Amino Acid Catabolic Process Thymine Metabolic Process Brown Fat Cell Differentiation	Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine Regulation Of Membrane Potential Nervous System Process Excitatory Postsynaptic Potential Regulation Of Synaptic Vesicle Exocytosis
Pathways		Branched-chain amino acid catabolism	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs		NADH	Nicotine Butabarbital Ethanol
Diseases
GWAS		Blood protein levels ( 28240269) Red blood cell count ( 32888494) Red cell distribution width ( 27863252) Refractive error ( 32231278)	Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Airflow obstruction ( 22837378) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 22080838 28166215 19300482 20173748 33909500) Cotinine levels in smokers with chronic obstructive pulmonary disease ( 29631575) Diffusing capacity of carbon monoxide ( 30694715) Emphysema distribution in smoking ( 27669027) Emphysema imaging phenotypes ( 26030696) Exhaled carbon monoxide levels ( 25072098) Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) FagerstrÓ§m test for nicotine dependence ( 31294817) Local histogram emphysema pattern ( 25006744) Lung adenocarcinoma ( 28604730 19836008) Lung cancer ( 31577861 18385676 28604730 18385738 18780872 27393504) Lung cancer in ever smokers ( 28604730) Nicotine dependence ( 18385739 26440539) Non-small cell lung cancer ( 31326317) Parental lifespan ( 30642433 29030599) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (father's age at death) ( 29227965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pre bronchodilator FEV1 ( 26634245) Pre bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary artery enlargement and chronic obstructive pulmonary disease ( 25101718) Pulmonary function ( 21946350) Schizophrenia ( 25056061 29483656) Serum albumin level ( 23022100) Small cell lung carcinoma ( 28604730) Smoking behavior ( 22832964 20418889) Smoking behaviour (cigarettes smoked per day) ( 30679032) Smoking cessation ( 33082346) Smoking status (heavy vs light) ( 28520984) Time to smoke first cigarette in the morning ( 31294817) Urate levels ( 31578528) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		4 interacting genes: CHRNA5 LMO2 NDRG4 OGT	6 interacting genes: ALDH6A1 CHRNA3 CHRNB4 CRABP1 LRP2BP SEMA7A
Entrez ID		4329	1138
HPRD ID		04416	00334
Ensembl ID		ENSG00000119711	ENSG00000169684
Uniprot IDs		A0A024R6G4 Q02252	H0YM98 P30532 Q6EWN4
PDB IDs
Enriched GO Terms of Interacting Partners?
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