MMP16 and DECR1

		MMP16	DECR1
Description		matrix metallopeptidase 16	2,4-dienoyl-CoA reductase 1
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GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Extracellular Matrix	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Catalytic Complex
	Molecular Function	Metalloendopeptidase Activity Enzyme Activator Activity Zinc Ion Binding Metalloaminopeptidase Activity	2,4-dienoyl-CoA Reductase (NADPH) Activity Identical Protein Binding NADPH Binding
	Biological Process	Skeletal System Development Endochondral Ossification Proteolysis Protein Processing Extracellular Matrix Organization Collagen Catabolic Process Chondrocyte Proliferation Embryonic Cranial Skeleton Morphogenesis Regulation Of Catalytic Activity Craniofacial Suture Morphogenesis	Fatty Acid Beta-oxidation Positive Regulation Of Cold-induced Thermogenesis
Pathways		Activation of Matrix Metalloproteinases	mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
Drugs		Marimastat Batimastat	Nicotinamide adenine dinucleotide phosphate 6-METHYL-2(PROPANE-1-SULFONYL)-2H-THIENO[3,2-D][1,2,3]DIAZABORININ-1-OL
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 31043756) Body mass index and cholesterol (psychopharmacological treatment) ( 22417934) Body shape index ( 34021172) Cerebral amyloid deposition (PET imaging) ( 26252872) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Heel bone mineral density ( 30598549) Irritable mood ( 29500382) Migraine without aura ( 23793025) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 21926974 29483656 22688191 30285260 23974872) Sweet taste perception in obesity with metabolic syndrome ( 31005965) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Blood protein levels ( 30072576)
Interacting Genes		5 interacting genes: DECR1 DNAAF5 KISS1 LRP1 PIP4P2	4 interacting genes: APP CLCN3 HGS MMP16
Entrez ID		4325	1666
HPRD ID		03776	01959
Ensembl ID		ENSG00000156103	ENSG00000104325
Uniprot IDs		P51512	A0A024R9D7 Q16698
PDB IDs		1RM8	1W6U 1W73 1W8D
Enriched GO Terms of Interacting Partners?
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