MMP9 and TIMP3

Number of citations of the paper that reports this interaction (PubMedID 11827795)
10

Data Source:
HPRD (in vivo, in vitro)

		MMP9	TIMP3
Description		matrix metallopeptidase 9	TIMP metallopeptidase inhibitor 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Nucleus Extracellular Matrix Platelet Dense Granule Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Identical Protein Binding	Protease Binding Protein Binding Metalloendopeptidase Inhibitor Activity Metal Ion Binding
	Biological Process	Skeletal System Development Ossification Positive Regulation Of Protein Phosphorylation Proteolysis Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Macrophage Differentiation Positive Regulation Of Cell Migration Collagen Catabolic Process Cellular Response To Reactive Oxygen Species Endodermal Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Keratinocyte Migration Cellular Response To Cadmium Ion Cellular Response To UV-A Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Neuroinflammatory Response Positive Regulation Of Receptor Binding Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cation Channel Activity Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Visual Perception Response To Hormone Response To Organic Substance Negative Regulation Of Endopeptidase Activity Response To Cytokine Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway Negative Regulation Of Metalloendopeptidase Activity
Pathways		Signaling by SCF-KIT Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Extra-nuclear estrogen signaling	Platelet degranulation
Drugs		Glutathione Marimastat Minocycline Captopril Glucosamine Zinc 2-Amino-N,3,3-Trimethylbutanamide 2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid AE-941 PG-530742 Endostatin 5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE (2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE (3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACID Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Pimagedine
Diseases
GWAS		Abdominal aortic aneurysm ( 27899403) Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Coronary artery disease ( 33020668) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 23128233) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mild influenza (H1N1) infection ( 26379185) Systemic sclerosis ( 29293537)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 23455636 21665990) Alzheimer's disease progression score ( 29860282) Blood protein levels ( 28240269) Metabolite levels ( 23823483) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Triglyceride levels ( 31170924)
Interacting Genes		33 interacting genes: AREG BTC CD44 COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 CXCL1 CXCL5 CXCL6 CXCL8 EPHB2 FN1 HAPLN1 KISS1 LCN2 MMP10 MMP26 MMP7 PLG PRSS2 PZP RECK TFPI TGFBI THBS1 THBS2 TIMP3 WFDC12	8 interacting genes: ADAM17 EFEMP1 KDR MMP13 MMP14 MMP2 MMP3 MMP9
Entrez ID		4318	7078
HPRD ID		00387	01785
Ensembl ID		ENSG00000100985	ENSG00000100234
Uniprot IDs		P14780	P35625
PDB IDs		1GKC 1GKD 1ITV 1L6J 1LKG 2OVX 2OVZ 2OW0 2OW1 2OW2 4H1Q 4H2E 4H3X 4H82 4HMA 4JIJ 4JQG 4WZV 4XCT 5CUH 5I12 5TH6 5TH9 5UE3 5UE4 6ESM	3CKI
Enriched GO Terms of Interacting Partners?
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