MMP1 and TFPI

Number of citations of the paper that reports this interaction (PubMedID 10859319)
27

Data Source:
HPRD (in vitro)

		MMP1	TFPI
Description		matrix metallopeptidase 1	tissue factor pathway inhibitor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix	Extracellular Region Extracellular Space Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Anchored Component Of Membrane
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Zinc Ion Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Protein-containing Complex Assembly Cellular Protein Metabolic Process Cellular Response To UV-A	Blood Coagulation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Blood Coagulation Response To Estradiol Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Steroid Hormone Stimulus
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Basigin interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling	Extrinsic Pathway of Fibrin Clot Formation
Drugs		Marimastat CGS-27023 N-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID [[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE	Coagulation factor VIIa Recombinant Human Dalteparin Andexanet alfa
Diseases
GWAS		Blood protein levels ( 30072576 28240269) Blood protein levels in cardiovascular risk ( 28369058)	Apolipoprotein A1 levels ( 32203549) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diffusing capacity of carbon monoxide ( 30694715) Heart rate ( 23583979) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Lung adenocarcinoma ( 28604730) Serum immune biomarker levels ( 32066700) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		17 interacting genes: ACAN BCAN BSG CCL13 CCL2 CCL7 CD44 CMA1 COL2A1 IGFBP3 ITGA2 MMP7 SERPINA3 SOX8 TFPI TIMP1 TNFSF11	10 interacting genes: APP ELANE F10 MMP1 MMP12 MMP7 MMP8 MMP9 PRSS3 THBS1
Entrez ID		4312	7035
HPRD ID		00384	01064
Ensembl ID		ENSG00000196611	ENSG00000003436
Uniprot IDs		B4DN15 P03956 Q53G95	P10646
PDB IDs		1AYK 1CGE 1CGF 1CGL 1HFC 1SU3 2AYK 2CLT 2J0T 2TCL 3AYK 3SHI 4AUO 4AYK 966C	1ADZ 1IRH 1TFX 4BQD 4DTG 5NMV 6BX8
Enriched GO Terms of Interacting Partners?
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