MLH1 and KPNA2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MLH1	KPNA2
Description		mutL homolog 1	karyopherin subunit alpha 2
Image
GO Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Chiasma Late Recombination Nodule Membrane Mismatch Repair Complex MutLalpha Complex	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Membrane Host Cell Extrinsic Component Of Postsynaptic Specialization Membrane Glutamatergic Synapse
	Molecular Function	Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Guanine/thymine Mispair Binding MutSalpha Complex Binding	RNA Binding Protein Binding Nuclear Localization Sequence Binding Histone Deacetylase Binding Nuclear Import Signal Receptor Activity
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Male Meiosis Chromosome Segregation Homologous Chromosome Pairing At Meiosis Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Bacterium Female Meiosis Chromosome Segregation Somatic Hypermutation Of Immunoglobulin Genes Meiotic Metaphase I Plate Congression Meiotic Telomere Clustering Isotype Switching Negative Regulation Of Mitotic Recombination Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Oogenesis Meiotic Spindle Midzone Assembly	Regulation Of DNA Recombination DNA Metabolic Process NLS-bearing Protein Import Into Nucleus Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Postsynapse To Nucleus Signaling Pathway Positive Regulation Of Viral Life Cycle
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes Meiotic recombination	CaMK IV-mediated phosphorylation of CREB ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Sensing of DNA Double Strand Breaks Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) Liver enzyme levels (alanine transaminase) ( 33972514) Platelet distribution width ( 32888494) Proximal colorectal cancer ( 33632709) Schizophrenia ( 28991256) Subjective response to lithium treatment ( 26503763)	Brain morphology (MOSTest) ( 32665545) Feeling lonely ( 29500382) General risk tolerance (MTAG) ( 30643258) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889)
Interacting Genes		141 interacting genes: - ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ALDOB ANXA6 AP1B1 AP2B1 APRT ARAF ASS1 ATF2 BAAT BLM BRCA1 BTBD2 C9orf152 CAB39L CAPN5 CASP3 CBY2 CCDC180 CCDC33 CCDC74B CDCA7L CDKL5 CEP126 CEP76 CKAP4 CKB CTSV CYLC2 DDX47 EEF1G EEF2 EIF2A ELP6 ENKD1 EXO1 EXOC3 FAM228A FAM50B FAM90A1 FAN1 FBXO32 FCGBP FLNB FRAT2 FRMD6 GABARAP GPX1 GSTP1 HDAC6 IGKC ISY1 KPNA2 KPNA5 KPRP LEF1 LGALS4 LUC7L3 LY96 MAGEA8 MAP2K6 MBD3L1 MBD4 MLH3 MORN3 MPG MSH3 MSH4 MSH5 MUC2 MYC MYL6 MYOG NANOS3 NDRG1 NELFA NFIX NME4 NT5C3B ORC4 PARP12 PARVA PCNA PER2 PIP4K2B PMS1 PMS2 PPP1R13B PPP2CB PRR5L PSMA1 PTGDS PTPN3 PTPRH RAD23B RAD9A RADX RAPGEFL1 RBM48 RSPH3 SEC61A1 SELENBP1 SERPINF1 SMAD1 SPATA8 SQSTM1 STAP2 STX17 SYF2 TASOR2 TDRD7 TFAP2D TLE5 TRIM23 TRIM29 TRMO TSGA13 TXN TXN2 U2AF1 UBOX5 VAMP8 XPA ZBED1 ZC3H11A ZER1 ZFP57 ZFP90 ZMAT5 ZNF177 ZNF212 ZNF474 ZNF559-ZNF177 ZNF774	112 interacting genes: ACTN1 ACTN4 ANKIB1 AP2B1 APOBEC1 APP ARL4A ARL5A ATXN3 BAG6 BRCA1 BTBD2 CASP2 CCDC107 CDA CDC42 CDK5RAP3 CHD3 CHEK2 CORO1B CREB3L3 CREBBP CSE1L CSNK1A1 CUL4B DCPS DCTN2 DDIT3 EP300 EPB41 FEZ2 FN1 FTH1 GART GMCL1 GRB2 GTF2IRD1 H1-0 HAP1 HMG20A HNRNPC HOMER2 HOMEZ HSPA4 IFT20 IMMT INO80E ITK JUN KLC4 KPNB1 KRT18 KRT40 KRT8 LAMB2 LEF1 LZTS2 MAGED1 MAGEH1 MDFI MLH1 MORC3 MORF4L1 MVP NECAB2 NFE2L2 NFKBIB NMNAT1 NR3C1 NUP153 NUP50 NUP62 NUTM1 OGT PAX5 PLAG1 PNMA5 PRKD3 PTMA RAG1 RAN RANBP2 RBM48 RBPMS RECQL RELA RELB RGL2 RILP RNMT SART3 SERTAD3 SGK1 SLC2A2 SPRY1 SRPK1 SUMO2 TADA2A TAF3 TAF8 TANK TBPL2 TP53 TRAF1 TRIM54 TSC22D4 TXNIP UBR5 USHBP1 ZBTB7B ZC3H12A ZNF131
Entrez ID		4292	3838
HPRD ID		00390	02818
Ensembl ID		ENSG00000076242	ENSG00000182481
Uniprot IDs		A0A024R2S9 P40692 Q59EG3	P52292
PDB IDs		3RBN 4P7A 5U5P	1EFX 1QGK 1QGR 3FEX 3FEY 3WPT 4E4V 4WV6 5H43
Enriched GO Terms of Interacting Partners?
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