ASAH1 and CAMK1D

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		ASAH1	CAMK1D
Description		N-acylsphingosine amidohydrolase 1	calcium/calmodulin dependent protein kinase ID
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Lysosome Early Endosome Endoplasmic Reticulum Lysosomal Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Intracellular Anatomical Structure Nucleus Cytoplasm
	Molecular Function	Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides N-acylsphingosine Amidohydrolase Activity Fatty Acid Amide Hydrolase Activity Ceramidase Activity	Calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Fatty Acid Metabolic Process Keratinocyte Differentiation Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Ceramide Catabolic Process Regulation Of Steroid Biosynthetic Process Regulation Of Programmed Necrotic Cell Death Cellular Response To Tumor Necrosis Factor	Inflammatory Response Nervous System Development Positive Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Phagocytosis Regulation Of Dendrite Development Positive Regulation Of Respiratory Burst Regulation Of Granulocyte Chemotaxis Positive Regulation Of Neutrophil Chemotaxis
Pathways		Glycosphingolipid metabolism Neutrophil degranulation
Drugs			N-(5-METHYL-1H-PYRAZOL-3-YL)-2-PHENYLQUINAZOLIN-4-AMINE Fostamatinib
Diseases
GWAS		Atrial fibrillation ( 28416818 30061737 29892015) Night sleep phenotypes ( 27126917) Obesity ( 21552555) Type 2 diabetes ( 32499647)	Anorexia nervosa ( 23568457) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Bipolar disorder ( 31043756) Body mass index ( 28892062) Borderline personality disorder ( 28632202) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery aneurysm in Kawasaki disease ( 27171184) Eating disorders ( 23568457) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Headache ( 29397368) Height ( 31562340) Household income (MTAG) ( 31844048) Obesity-related traits ( 23251661) Obstructive sleep apnea (BMI adjusted) ( 33243845) QT interval (drug interaction) ( 23459443) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Tea consumption ( 31046077) Triglyceride levels in HIV infection ( 33109212) Type 2 diabetes ( 22885922 18372903 26961502 20862305 29358691 30297969 26818947 32499647 30718926)
Interacting Genes		6 interacting genes: CAMK1D HSPB2 SETDB1 SMPD1 SRPK1 TSC22D1	13 interacting genes: APP ASAH1 BNIP3L CAMKK1 CDC25A CUL3 GMFG LCK LRRK2 NEDD4 NEDD4L POT1 TNFSF13
Entrez ID		427	57118
HPRD ID		01969	06409
Ensembl ID		ENSG00000104763	ENSG00000183049
Uniprot IDs		A8K0B6 Q13510 Q53H01	Q5SQQ7 Q8IU85
PDB IDs		5U7Z 6MHM	2JC6 6QP5 6T28 6T29 6T6F
Enriched GO Terms of Interacting Partners?
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