MET and INPP5D

Number of citations of the paper that reports this interaction (PubMedID 15735664)
17

Data Source:
HPRD (two hybrid)

		MET	INPP5D
Description		MET proto-oncogene, receptor tyrosine kinase	inositol polyphosphate-5-phosphatase D
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Cell Surface Integral Component Of Membrane Receptor Complex	Cytosol Cytoskeleton Plasma Membrane Membrane Raft
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Hepatocyte Growth Factor-activated Receptor Activity Protein Binding ATP Binding Semaphorin Receptor Activity Protein Phosphatase Binding Identical Protein Binding	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity SH3 Domain Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity
	Biological Process	Endothelial Cell Morphogenesis Liver Development Phagocytosis Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Negative Regulation Of Autophagy Cell Migration Peptidyl-tyrosine Phosphorylation Neuron Differentiation Pancreas Development Positive Regulation Of Microtubule Polymerization Positive Regulation Of Kinase Activity Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Growth Factor Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Positive Chemotaxis Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Protein Kinase B Signaling Establishment Of Skin Barrier Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Semaphorin-plexin Signaling Pathway Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Endothelial Cell Chemotaxis	Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Determination Of Adult Lifespan Negative Regulation Of Signal Transduction Immunoglobulin Mediated Immune Response Negative Regulation Of B Cell Proliferation Negative Regulation Of Interleukin-6 Production Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Monocyte Differentiation Negative Regulation Of Neutrophil Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Phosphatidylinositol Dephosphorylation Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Sema4D mediated inhibition of cell attachment and migration RAF/MAP kinase cascade MET Receptor Activation Negative regulation of MET activity PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates RAS signaling MET activates PI3K/AKT signaling MET activates PTPN11 MET activates PTK2 signaling InlB-mediated entry of Listeria monocytogenes into host cell InlB-mediated entry of Listeria monocytogenes into host cell MET interacts with TNS proteins MET activates RAP1 and RAC1 MET receptor recycling MET activates STAT3 MECP2 regulates neuronal receptors and channels	Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Downstream TCR signaling PECAM1 interactions Interleukin receptor SHC signaling
Drugs		K-252a SGX-523 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol AMG-208 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE Crizotinib Cabozantinib Capmatinib Fostamatinib Tivantinib Brigatinib Amuvatinib
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Gamma glutamyl transferase levels ( 29403010 33339817) HDL cholesterol levels ( 28334899) Hematocrit ( 28017375) Lung function (FEV1/FVC) ( 30804560) Medication use (beta blocking agents) ( 31015401) Multiple sclerosis (severity) ( 19010793) PR segment duration ( 24850809) Pulse pressure ( 30578418) Resting heart rate ( 29769521 27798624) Triglyceride levels ( 28334899) Triglycerides ( 24097068) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Contrast sensitivity ( 24152035) Crohn's disease ( 22412388 23128233) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Family history of Alzheimer's disease ( 30617256) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Perceived unattractiveness to mosquitoes ( 28199695) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Serum alkaline phosphatase levels ( 33547301) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		124 interacting genes: ABL2 BAG1 BCAR3 BLK BTK CAMSAP3 CASP3 CAV1 CBL CCND2 CD44 CDK4 CDK6 CDKN2B CNR1 CRK CTNNB1 CTTN DAPK3 DCN DNAJA3 EGFR EPHA2 ERBB2 FAS FES FGFR4 FGR FOXA3 FZR1 GAB1 GLIS2 GLMN GRB14 GRB2 GRB7 HCK HGF HGS HSH2D INPP5D INPPL1 ITGB1 ITGB4 ITK KCND2 KDELR2 KLK2 LATS2 LCK LYN MAP2K3 MAP2K5 MATK MRPL17 MUC20 MYC NCK1 NCK2 NF2 PABPC1 PCBD2 PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PLXNB1 PTK6 PTPN11 PTPRB PTPRJ RAF1 RANBP10 RANBP9 RASA1 RASSF1 RASSF7 SH2B1 SH2B2 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3C SH3BP2 SH3KBP1 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA2 SLC26A3 SLC26A4 SMC1A SNAPIN SND1-IT1 SNX2 SOCS1 SOCS2 SOCS3 SOCS5 SOCS6 SPSB1 SRC STAP1 STAT3 STK11 SYK TEC TERT TNS1 TNS2 TNS3 TNS4 TP53 TXK VAV1 VAV2 VAV3 YES1 ZAP70	46 interacting genes: ARAP1 CD22 CD300LF CRKL CSF1R CSF3R CYSRT1 DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR1B FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP6-3 LILRB4 LYN MET NOTCH2NLA PAX6 PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 SLAMF1 XIAP ZDHHC17
Entrez ID		4233	3635
HPRD ID		01280	09033
Ensembl ID		ENSG00000105976	ENSG00000168918
Uniprot IDs		A0A024R728 A0A024R759 B4DLF5 E6Y365 P08581	Q92835
PDB IDs		1FYR 1R0P 1R1W 1SHY 1SSL 1UX3 2G15 2RFN 2RFS 2UZX 2UZY 2WD1 2WGJ 2WKM 3A4P 3BUX 3C1X 3CCN 3CD8 3CE3 3CTH 3CTJ 3DKC 3DKF 3DKG 3EFJ 3EFK 3F66 3F82 3I5N 3L8V 3LQ8 3Q6U 3Q6W 3QTI 3R7O 3RHK 3U6H 3U6I 3VW8 3ZBX 3ZC5 3ZCL 3ZXZ 3ZZE 4AOI 4AP7 4DEG 4DEH 4DEI 4EEV 4GG5 4GG7 4IWD 4K3J 4KNB 4MXC 4O3T 4O3U 4R1V 4R1Y 4XMO 4XYF 5DG5 5EOB 5EYC 5EYD 5HLW 5HNI 5HO6 5HOA 5HOR 5HTI 5LSP 5T3Q 5UAB 5UAD 5YA5 6GCU 6I04 6SD9 6SDC 6SDD 6SDE 6UBW 7B3Q 7B3T 7B3V 7B3W 7B3Z 7B40 7B41 7B42 7B43 7B44	2YSX 5RW2 5RW3 5RW4 5RW5 5RW6 5RW7 5RW8 5RW9 5RWA 5RWB 5RWC 5RWD 5RWE 5RWF 5RWG 5RWH 5RWI 5RWJ 5RWK 5RWL 5RWM 5RWN 5RWO 5RWP 5RWQ 5RWR 5RWS 5RWT 5RWU 5RWV 5RWW 5RWX 5RWY 5RWZ 5RX0 5RX1 5RX2 5RX3 5RX4 5RX5 5RX6 5RX7 5RX8 5RX9 5RXA 5RXB 5RXC 5RXD 5RXE 5RXF 5RXG 5RXH 5RXI 5RXJ 5RXK 5RXL 5RXM 5RXO 5RXP 5RXQ 5RXR 5RXS 5RXT 5RXU 5RXV 5RXW 5RXX 5RXY 5RXZ 5RY0 5RY1 5RY2 5RY3 5RY4 5RY5 5RY6 5RY7 5RY8 5RY9 5RYA 5RYB 5RYC 5RYD 5RYE 5RYF 5RYG 5RYH 5RYI 5RYJ 5RYK 5RYL 6IBD 6XY7
Enriched GO Terms of Interacting Partners?
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