MAP3K4 and MAP2K7

Number of citations of the paper that reports this interaction (PubMedID 15866172)
49

Data Source:
BioGRID (pull down)

		MAP3K4	MAP2K7
Description		mitogen-activated protein kinase kinase kinase 4	mitogen-activated protein kinase kinase 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol
	Molecular Function	MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity	Magnesium Ion Binding MAP Kinase Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Placenta Development Protein Phosphorylation Response To UV-C Regulation Of Gene Expression Male Germ-line Sex Determination Positive Regulation Of Telomere Maintenance Via Telomerase Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Positive Regulation Of Telomerase Activity Chorionic Trophoblast Cell Differentiation Positive Regulation Of P38MAPK Cascade Positive Regulation Of Telomere Capping	MAPK Cascade Apoptotic Process Response To Osmotic Stress Signal Transduction JNK Cascade Response To Heat Response To UV Peptidyl-tyrosine Phosphorylation Positive Regulation Of Telomere Maintenance Via Telomerase Response To Tumor Necrosis Factor Fc-epsilon Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Stress-activated MAPK Cascade Positive Regulation Of Telomerase Activity Positive Regulation Of ERK1 And ERK2 Cascade Cellular Senescence Positive Regulation Of Telomere Capping
Pathways			Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins
Drugs		Fostamatinib
Diseases
GWAS		Aging ( 22773346) Blood protein levels ( 28240269) Cognitive decline rate in late mild cognitive impairment ( 26252872) Lipoprotein (a) levels ( 26377243) Ovarian disease with few adhesions ( 28333195)	Fasting insulin ( 34059833) HDL cholesterol levels ( 32203549) Mean corpuscular hemoglobin concentration ( 32888494) Metabolite levels ( 23823483) Type 2 diabetes ( 30297969 32499647)
Interacting Genes		27 interacting genes: ANXA2 AXIN1 BUB1B CDC42 CHUK CNTRL DIXDC1 EPHB4 GADD45A GADD45B GADD45G GSK3B MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK13 MFHAS1 PTK2B PTPN11 RAC1 RACGAP1 RUNX2 TPR TRAF4 YWHAZ	33 interacting genes: ARR3 ATF4 CFLAR CNKSR1 DUSP19 DUSP22 GADD45B ICAM1 JUN LPXN LRRK2 MAP3K1 MAP3K11 MAP3K12 MAP3K13 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 MAPT RANBP2 RPL30 TRAF6 TRIB1 VRK2
Entrez ID		4216	5609
HPRD ID		03886	04309
Ensembl ID		ENSG00000085511	ENSG00000076984
Uniprot IDs		Q9P1M2 Q9Y6R4	B4DV95 O14733
PDB IDs			2DYL 3WZU 4UX9 5B2K 5B2L 5B2M 5Y8U 5Y90 5Z1D 5Z1E 6IB0 6IB2 6QFL 6QFR 6QFT 6QG4 6QG7 6QHO 6QHR 6YFZ 6YG0 6YG1 6YG2 6YG3 6YG4 6YG5 6YG6 6YG7 6YZ4 7CBX
Enriched GO Terms of Interacting Partners?
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