MBL2 and MAD2L1

Number of citations of the paper that reports this interaction (PubMedID 11804586)
141

Data Source:
HPRD (in vitro, in vivo)

		MBL2	MAD2L1
Description		mannose binding lectin 2	mitotic arrest deficient 2 like 1
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Cell Surface Collagen-containing Extracellular Matrix	Kinetochore Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Pore Nuclear Basket Perinuclear Region Of Cytoplasm Mitotic Spindle
	Molecular Function	Signaling Receptor Binding Protein Binding Mannose Binding Identical Protein Binding Calcium-dependent Protein Binding	Protein Binding Protein C-terminus Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Complement Activation, Lectin Pathway Acute-phase Response Complement Activation, Classical Pathway Response To Oxidative Stress Opsonization Defense Response To Bacterium Innate Immune Response Negative Regulation Of Viral Process Defense Response To Gram-positive Bacterium	Establishment Of Mitotic Spindle Orientation Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Cell Division Establishment Of Centrosome Localization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of Ubiquitin Protein Ligase Activity
Pathways		Lectin pathway of complement activation Initial triggering of complement	Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		O3-Sulfonylgalactose Methyl alpha-D-mannoside 4-(Hydrogen sulfate)-beta-D-galactopyranose Methyl beta-L-fucopyranoside N-acetyl-alpha-neuraminic acid alpha-L-methyl-fucose Alpha-Methyl-N-Acetyl-D-Glucosamine
Diseases
GWAS		Age-related macular degeneration ( 23326517) Blood protein levels ( 30072576 29875488 28240269) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chin dimples ( 27182965) Emphysema imaging phenotypes ( 26030696) Femoral neck bone mineral density ( 29499414) Fractures ( 30158200 30598549) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414 22504420) Metabolite levels ( 23823483) Monobrow ( 27182965) Rosacea symptom severity ( 29771307)	Coronary artery disease ( 32469254 28714974 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) F-cell distribution in sickle cell anaemia ( 21326311) HIV-1 viral setpoint ( 22174851) Loneliness (multivariate analysis) ( 27629369) Myocardial infarction ( 33532862) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: ANK3 CALCR CALR CD93 KRT1 MAD2L1 MASP1 MASP2 PTPRC UBQLN2	27 interacting genes: ADAM17 ANAPC2 ANAPC4 APP BBS7 CCNA2 CDC16 CDC20 CDC27 CSF2RB DEPDC5 EPM2AIP1 ESR2 H3C1 INSR KEAP1 MAD1L1 MAD2L1BP MAD2L2 MBL2 NDC80 RABAC1 REV3L SDCBP TRIP13 TSC22D4 UBD
Entrez ID		4153	4085
HPRD ID		01107	03274
Ensembl ID		ENSG00000165471	ENSG00000164109
Uniprot IDs		P11226	Q13257
PDB IDs		1HUP	1DUJ 1GO4 1KLQ 1S2H 2QYF 2V64 2VFX 3GMH 5KHU 5LCW 6F0X 6TLJ
Enriched GO Terms of Interacting Partners?
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