MATN1 and COL2A1

Number of citations of the paper that reports this interaction (PubMedID 10196235)
15

Data Source:
HPRD (in vivo)

		MATN1	COL2A1
Description		matrilin 1	collagen type II alpha 1 chain
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Collagen-containing Extracellular Matrix	Extracellular Region Collagen Trimer Collagen Type II Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength MHC Class II Protein Binding Identical Protein Binding Proteoglycan Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Growth Plate Cartilage Chondrocyte Morphogenesis Regulation Of Bone Mineralization Protein-containing Complex Assembly	Skeletal System Development Cartilage Condensation Tissue Homeostasis Endochondral Ossification Chondrocyte Differentiation Heart Morphogenesis Proteoglycan Metabolic Process Central Nervous System Development Visual Perception Sensory Perception Of Sound Regulation Of Gene Expression Extracellular Matrix Organization Collagen Fibril Organization Notochord Development Inner Ear Morphogenesis Cartilage Development Roof Of Mouth Development Limb Bud Formation Embryonic Skeletal Joint Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis Otic Vesicle Development Cellular Response To BMP Stimulus Anterior Head Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		ECM proteoglycans	Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization
Drugs			Collagenase clostridium histolyticum
Diseases
GWAS		Broad depression or schizophrenia ( 30626913) Low high density lipoprotein cholesterol levels ( 26879886) Monocyte count ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Schizophrenia ( 28991256 30285260) Serum alkaline phosphatase levels ( 33339817)	Lymphocyte counts ( 32888494) Macular thickness ( 30535121) Neutrophil percentage of white cells ( 32888494) Retinal detachment or retinal break ( 31816047) Rheumatoid arthritis ( 30891314) Triglyceride levels ( 32902719)
Interacting Genes		6 interacting genes: B4GALT2 COL2A1 ITGA1 MATN2 MATN3 MATN4	33 interacting genes: ANXA5 BGN BMP2 C1QA CHAD COL6A1 COL9A2 COL9A3 COMP DDR1 FGF7 FN1 HTRA1 HYAL1 ITGA2B KEAP1 LOXL4 MAG MATN1 MMP1 MMP13 PCOLCE PDGFA PDGFB PDIA2 PKD1 PRELP RELA SPARC TGFB1 TGFBI THBS1 TNFRSF10A
Entrez ID		4146	1280
HPRD ID		00276	00361
Ensembl ID		ENSG00000162510	ENSG00000139219
Uniprot IDs		P21941	P02458
PDB IDs			1U5M 2FSE 2SEB 5NIR 5OCX 5OCY 6BIN 6NIX
Enriched GO Terms of Interacting Partners?
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