MATK and GPX4

		MATK	GPX4
Description		megakaryocyte-associated tyrosine kinase	glutathione peroxidase 4
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GO Annotations	Cellular Component	Cytosol Membrane	Nucleus Nuclear Envelope Mitochondrion Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Selenium Binding Identical Protein Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity
	Biological Process	Protein Phosphorylation Positive Regulation Of Cell Population Proliferation Peptidyl-tyrosine Phosphorylation	Chromatin Organization Phospholipid Metabolic Process Glutathione Metabolic Process Response To Oxidative Stress Spermatogenesis Aging Arachidonic Acid Metabolic Process Lipoxygenase Pathway Response To Estradiol Long-chain Fatty Acid Biosynthetic Process Regulation Of Inflammatory Response Protein Polymerization Cellular Oxidant Detoxification Negative Regulation Of Ferroptosis
Pathways		Downregulation of ERBB2 signaling	Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives
Drugs		Fostamatinib	Glutathione Glutathione Glutathione disulfide
Diseases
GWAS		Obesity-related traits ( 23251661)	Advanced age-related macular degeneration ( 26691988) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 31174203) Crohn's disease ( 28067908 21102463 23128233) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) hemolysis of donated blood (oxidative) ( 34014839) Inflammatory bowel disease ( 28067908) Keratinocyte cancer (MTAG) ( 31174203) Liver enzyme levels (alkaline phosphatase) ( 33972514) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		26 interacting genes: AKT1 AR CACNA1A CD36 ERBB2 ERBB3 ERBB4 EWSR1 FRS3 GPX4 HSPA5 HSPA9 ILK KIT LRRK1 LRRK2 LYN MET NFIX NTRK1 PTK2B PTPRD PXN SIRPA SMURF1 SRC	10 interacting genes: APBA3 EGR4 FUT5 GAMT GTF2F1 MAPK13 MATK PARK7 PRDX6 ZNF197
Entrez ID		4145	2879
HPRD ID		02496	11819
Ensembl ID		ENSG00000007264	ENSG00000167468
Uniprot IDs		F1T0G6 P42679	P36969 Q6PI42
PDB IDs		1JWO 1X6G 3US4	2GS3 2OBI 5H5Q 5H5R 5H5S 6ELW 6HKQ 6HN3
Enriched GO Terms of Interacting Partners?
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