MAPT and CSNK2A1

Number of citations of the paper that reports this interaction (PubMedID 15882073)
9

Data Source:
BioGRID (enzymatic study)

		MAPT	CSNK2A1
Description		microtubule associated protein tau	casein kinase 2 alpha 1
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Microtubule Plasma Membrane Microtubule Cytoskeleton Membrane Nuclear Speck Axon Dendrite Growth Cone Axolemma Nuclear Periphery Cytoplasmic Ribonucleoprotein Granule Somatodendritic Compartment Neuron Projection Neuronal Cell Body Dendritic Spine Cell Body Main Axon Membrane Raft Tubulin Complex Glial Cell Projection Neurofibrillary Tangle Axon Cytoplasm	Nucleus Nucleoplasm Cytosol Plasma Membrane Protein Kinase CK2 Complex Sin3 Complex NuRD Complex
	Molecular Function	DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Actin Binding Protein Binding Microtubule Binding SH3 Domain Binding Enzyme Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Apolipoprotein Binding Dynactin Binding Phosphatidylinositol Binding Identical Protein Binding Sequence-specific DNA Binding Chaperone Binding Protein Phosphatase 2A Binding Hsp90 Protein Binding Lipoprotein Particle Binding Histone-dependent DNA Binding Microtubule Lateral Binding Phosphatidylinositol Bisphosphate Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Identical Protein Binding Protein N-terminus Binding Hsp90 Protein Binding Protein Serine Kinase Activity
	Biological Process	Microtubule Cytoskeleton Organization Microglial Cell Activation Internal Protein Amino Acid Acetylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell-cell Signaling Memory Response To Lead Ion Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Mitochondrial Membrane Potential RRNA Metabolic Process Axonal Transport Of Mitochondrion Central Nervous System Neuron Development Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Neuron Projection Development Positive Regulation Of Superoxide Anion Generation Regulation Of Chromosome Organization Negative Regulation Of Kinase Activity Stress Granule Assembly Cellular Response To Heat Cellular Response To Reactive Oxygen Species Positive Regulation Of Axon Extension Microtubule Polymerization Astrocyte Activation Regulation Of Synaptic Plasticity Intracellular Distribution Of Mitochondria Generation Of Neurons Synapse Organization Regulation Of Calcium-mediated Signaling Protein Polymerization Axon Development Regulation Of Microtubule Cytoskeleton Organization Plus-end-directed Organelle Transport Along Microtubule Regulation Of Mitochondrial Fission Negative Regulation Of Mitochondrial Fission Supramolecular Fiber Organization Axonal Transport Regulation Of Cellular Response To Heat Regulation Of Long-term Synaptic Depression Positive Regulation Of Neuron Death Positive Regulation Of Protein Localization To Synapse Neurofibrillary Tangle Assembly Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Cellular Protein Localization Negative Regulation Of Tubulin Deacetylation Positive Regulation Of Diacylglycerol Kinase Activity Amyloid Fibril Formation Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Response To DNA Damage Stimulus	Protein Phosphorylation Apoptotic Process Cell Cycle Signal Transduction Positive Regulation Of Cell Population Proliferation Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Cell Growth Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Protein Catabolic Process Rhythmic Process Regulation Of Cell Cycle Chaperone-mediated Protein Folding Regulation Of Chromosome Separation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Caspase-mediated cleavage of cytoskeletal proteins	Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding ROS sensing by NFE2L2 Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity
Drugs		Lansoprazole Astemizole Paclitaxel Docetaxel Flortaucipir F-18	ATP (5-hydroxyindolo[1,2-a]quinazolin-7-yl)acetic acid 1,8-Di-Hydroxy-4-Nitro-Xanthen-9-One Resveratrol 1,8-Di-Hydroxy-4-Nitro-Anthraquinone Benzamidine 5,8-Di-Amino-1,4-Dihydroxy-Anthraquinone Quercetin Phosphoaminophosphonic Acid-Adenylate Ester Tetrabromo-2-Benzotriazole DIMETHYL-(4,5,6,7-TETRABROMO-1H-BENZOIMIDAZOL-2-YL)-AMINE S-METHYL-4,5,6,7-TETRABROMO-BENZIMIDAZOLE N1,N2-ETHYLENE-2-METHYLAMINO-4,5,6,7-TETRABROMO-BENZIMIDAZOLE Emodin 3,8-DIBROMO-7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE 19-(cyclopropylamino)-4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3,9]triazacyclohexadecin-8(9H)-one N,N'-DIPHENYLPYRAZOLO[1,5-A][1,3,5]TRIAZINE-2,4-DIAMINE 4-(2-(1H-IMIDAZOL-4-YL)ETHYLAMINO)-2-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE 2-(CYCLOHEXYLMETHYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE 2-(4-CHLOROBENZYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE 2-(4-ETHYLPIPERAZIN-1-YL)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE N-(3-(8-CYANO-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-2-YLAMINO)PHENYL)ACETAMIDE Dichlororibofuranosylbenzimidazole Quinalizarin Ellagic acid Fostamatinib
Diseases
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alcohol use disorder (consumption score) ( 30336701 33861876) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease ( 31473137) Alzheimer's disease in APOE e4- carriers ( 25778476) Aspartate aminotransferase levels ( 33547301) Atrial fibrillation ( 29892015) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive performance (processing speed) ( 31598132) Corticobasal degeneration ( 26077951) Experiencing mood swings ( 29500382) Feeling hurt ( 29500382) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Glaucoma (primary open-angle) ( 33627673) Handedness (Left-handed vs. non-left-handed) ( 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Handedness (non-right-handed vs right-handed) ( 31504236) HDL cholesterol levels ( 32203549) Head circumference (infant) ( 22504419) Headache ( 29397368) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172) Household income ( 31844048) Household income (MTAG) ( 31844048) Idiopathic pulmonary fibrosis ( 31710517 24429156) Immature fraction of reticulocytes ( 32888494) Interstitial lung disease ( 23583980) Intracranial volume ( 22504418) Leftâ€“right brain asymmetry ( 33723403) Lumbar spine bone mineral density ( 22504420) Male-pattern baldness ( 29146897 28196072) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (anilides) ( 31015401) Mood instability ( 31168069) Multiple system atrophy ( 27629089) Neuroticism ( 29255261) Neutrophil percentage of white cells ( 32888494) Oily fish consumption ( 32066663) Osteoarthrosis (time to event) ( 32589924) Parkinson's disease ( 20711177 21292315 19915575 25064009 31660654 24842889 28892059 22438815 20070850 21044948 24511991 21738487) Plasma t-tau levels ( 28100725) Pork consumption ( 32066663) Primary biliary cirrhosis ( 22961000) Progressive supranuclear palsy ( 30089514 21685912 31059154) QRS complex (12-leadsum) ( 27659466) Reaction time ( 29844566) Red blood cell count ( 32888494) Refractive error ( 32231278) Retinal detachment or retinal break ( 31816047) Serum alkaline phosphatase levels ( 33547301) Smoking initiation ( 33082346) Subcortical brain region volumes ( 25607358) Type 1 diabetes ( 34127860) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter integrity (mean diffusivity) ( 32358547)	Night sleep phenotypes ( 27126917) Pursuit maintenance gain ( 29064472)
Interacting Genes		129 interacting genes: AATF ABL1 ACTA1 ACTB ACTG1 AKT1 AMPH APOE ARHGEF40 BAG1 BRSK1 BRSK2 CALM1 CAMK2A CAPN1 CAPN2 CASP1 CASP3 CASP6 CASP7 CASP8 CDK1 CDK2 CDK5 CHEK1 CHEK2 CREBBP CSNK1A1 CSNK1D CSNK2A1 CTSD DUSP1 DYRK1A DYRK2 EGFR EP300 F2 FKBP1A FKBP5 FYN GRB2 GSK3A GSK3B HDAC6 HOOK3 HSP90AA1 HSPA8 HSPB1 HTRA1 LCK LGMN LRRK2 MAP2K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MARCHF7 MARK1 MARK2 MARK3 MARK4 MASP1 MELK NPEPPS OGT OTUB1 PACSIN1 PDIA2 PEG10 PHKG1 PIK3R1 PIN1 PKN1 PLCG1 PPP1CA PPP1CB PPP1CC PPP2CA PPP2CB PPP2R5A PPP5C PRKACA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCI PRKCZ PSEN1 PTK2B PTPA PTPN11 PWP2 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KB1 S100B SIK1 SNCA SPTB SQSTM1 SRC SRPK1 SRPK2 STAU1 STUB1 STXBP1 SYK TRAF6 TTBK1 TUBA1B TUBA4A TUBB TUBB3 UBB UBE2D2 UBE2D3 UBE2W USP9Y YWHAB YWHAZ	436 interacting genes: - ABCA1 ABCC1 ACACA ACAT2 ACE ACIN1 AIP AKAP8 AKT1 ALKBH5 ANP32B APEX1 APOE APP AQP4 ARL6IP4 ARMCX3 ARNT ARR3 ARRB2 ASIC3 ATF1 ATF2 ATG16L1 ATN1 ATP2B1 ATP5F1A AUTS2 BCLAF1 BDP1 BEND7 BHLHE41 BID BIRC6 BMS1 BRCA1 BRF1 BRMS1 C1orf109 C1orf35 C1R CALM1 CALU CANX CARD9 CASP2 CASQ2 CAV1 CAV2 CCDC116 CCDC6 CD2BP2 CD5 CDC25B CDC37 CDH1 CDK1 CDKN1A CFDP1 CHD4 CHUK CIRBP CLASP2 CLNS1A CLTB COPS2 COPS3 COPS7A CPSF6 CPSF7 CREB3L3 CREBBP CREM CSN1S1 CSN2 CSNK2B CT45A1 CTDP1 CTNNA1 CTNNB1 CUX2 DAXX DDIT3 DDX17 DDX21 DDX24 DDX3X DDX54 DEK DELEC1 DHX16 DHX38 DKC1 DNAJB2 DPF3 DTD1 DVL1 DVL3 ECD EEF1B2 EEF1D EGR1 EHMT2 EIF2B5 EIF2S1 EIF2S2 EIF3J EIF4B EIF4EBP1 EIF5 EIF5B ERH EXOSC9 F11R F5 FAF1 FAM133A FBXO28 FCHO1 FGF1 FGF2 FIBP FIP1L1 FKBP3 FKBP4 FLG FNBP4 FOS FTSJ3 FXR1 GABRR1 GABRR2 GANAB GAP43 GGA1 GMFB GMNN GPATCH2 GPATCH2L GPI GPN1 GRIN2A GRIN2B GSC2 GTF2A1 GTF2A1L GTF2F1 GYS1 HCLS1 HDAC1 HDAC2 HDAC3 HDGFL2 HDLBP HES6 HGS HIF1A HMGA1 HMGA2 HMOX2 HNRNPA2B1 HNRNPC HNRNPDL HNRNPL HOXB7 HOXC4 HSF1 HSP90AA1 HSP90AB1 HSP90B1 HSPA4 HSPB8 HSPH1 HTATSF1 IFI16 IFRD1 IGF2R IGFBP3 IL16 INF2 IRF2 IRS1 ITCH IWS1 JADE2 JUN KANK2 KDM1A KEAP1 KIF1C KIF24 KIF5C KLF1 KPNA4 L1CAM LARP1 LEO1 LGALS3 LHX3 LHX8 LHX9 LIG1 LRRC59 LSM14A LTV1 MAF1 MAGEA11 MAK16 MAPK1 MAPK14 MAPT MAX MAZ MCM2 MCM3 MDC1 MDM2 MEF2C MEOX1 MEOX2 MFAP1 MGMT MME MPHOSPH10 MRPL38 MRPL4 MS4A1 MSH6 MTDH MUS81 MYB MYC MYCN MYF5 MYH9 NAF1 NAP1L1 NAP1L4 NCAPD2 NCL NCOR1 NFKBIA NFKBIB NFYA NKX2-5 NMD3 NMT1 NOL3 NOLC1 NOP56 NOP58 NPM1 NRF1 NUP98 NXF1 OCLN OGDHL OGT OSBP OTUB1 PACS1 PAFAH1B1 PAK1 PAX5 PAX6 PAX7 PDAP1 PDCD4 PDIA6 PGK1 PGR PHF19 PIAS1 PIN1 PIN4 PIP4K2B PLEKHO1 PML PNN POLR2A POU6F2 PPAN PPP1R1B PPP1R2 PPP1R8 PRCC PRKACB PRNP PRPF38A PSEN2 PSIP1 PSMA3 PSMA4 PSME3IP1 PTEN PTPA PTPN1 PTPRC PURB RAD1 RAD51 RAD9A RANGAP1 RBM10 RBM17 RBM33 RBM39 RBMX REL RELA RGS19 RIOK1 RIOK2 RNF111 RNF7 RPL13 RPL5 RPL6 RPLP0 RPLP1 RPRD2 RPS18 RPS3 RPS6KB1 RRAD RRP12 RRP1B RRP9 RSF1 RSL1D1 SAFB SAP30BP SAT1 SCNN1A SEPTIN2 SERBP1 SERPINF1 SF3A1 SF3B1 SF3B2 SFPQ SHOX SLC18A2 SLC4A1AP SLIRP SMARCC2 SNAI2 SNCA SND1 SP1 SPATS2L SPI1 SPIB SPP1 SPTBN1 SQSTM1 SREK1 SRF SRRM1 SRRM2 SRRT SRSF10 SRSF11 SRSF2 SSB SSRP1 STAC3 STMN1 STX1A SUB1 SUDS3 SUGT1 SUPT5H SUPT6H SURF6 TCF7L2 TCOF1 TEPSIN TFAP2A TH THAP1 THOC5 THRAP3 TLE5 TMOD3 TMPO TNKS1BP1 TNP1 TOP1 TOP2A TP53 TP63 TP73 TRIM41 TSPY1 TSPYL2 UBAC1 UBE2D3 UBE2R2 UBTF USP24 USP48 USP7 UTP14A UTP18 VAMP4 VDR VHL VTN WAS WDR44 WDR55 WEE1 XK XKRY XRCC1 XRCC4 XRCC5 XRCC6 XRN2 YBX1 YWHAB YWHAQ ZC3H13 ZC3H15 ZC3H8 ZFC3H1 ZHX1 ZNF177 ZNF440 ZNF558 ZNF559-ZNF177 ZNF670 ZRANB2 ZSCAN25
Entrez ID		4137	1457
HPRD ID		01142	00277
Ensembl ID		ENSG00000186868	ENSG00000101266
Uniprot IDs		A0A024R9Y0 A0A024R9Y1 A0A024RA17 A0A024RA19 B3KTM0 P10636	P68400
PDB IDs		1I8H 2MZ7 2ON9 3OVL 4E0M 4E0N 4E0O 4FL5 4GLR 4NP8 4TQE 4Y32 4Y3B 4Y5I 5DMG 5E2V 5E2W 5HF3 5K7N 5MO3 5MP1 5MP3 5MP5 5N5A 5N5B 5NVB 5O3L 5O3O 5O3T 5V5B 5V5C 5ZIA 5ZV3 6BB4 6CVJ 6CVN 6DC8 6DC9 6DCA 6FBW 6FI5 6GK7 6GK8 6GX5 6H06 6HRE 6HRF 6LRA 6N4P 6NK4 6NWP 6NWQ 6ODG 6PXR 6QJH 6QJM 6QJP 6QJQ 6TJO 6TJX 6VH7 6VHA 6VHL 6VI3 6XLI	1JWH 1NA7 1PJK 2PVR 2ZJW 3AMY 3AT2 3AT3 3AT4 3AXW 3BQC 3C13 3FWQ 3H30 3JUH 3MB6 3MB7 3NGA 3NSZ 3OWJ 3OWK 3OWL 3PE1 3PE2 3PE4 3Q04 3Q9W 3Q9X 3Q9Y 3Q9Z 3QA0 3R0T 3RPS 3TAX 3U4U 3U87 3U9C 3W8L 3WAR 3WIK 3WIL 3WOW 4DGL 4FBX 4GRB 4GUB 4GYW 4GYY 4GZ3 4IB5 4KWP 4MD7 4MD8 4MD9 4NH1 4RLL 4UB7 4UBA 5B0X 5CLP 5CQU 5CQW 5CS6 5CSH 5CSP 5CSV 5CT0 5CTP 5CU0 5CU2 5CU3 5CU4 5CU6 5CVF 5CVG 5CVH 5CX9 5H8B 5H8E 5H8G 5HGV 5KU8 5KWH 5M44 5M4C 5M4F 5M4I 5MMF 5MMR 5MO5 5MO6 5MO7 5MO8 5MOD 5MOE 5MOH 5MOT 5MOV 5MOW 5MP8 5MPJ 5N1V 5N9K 5N9L 5N9N 5NQC 5OMY 5ONI 5OQU 5ORH 5ORJ 5ORK 5OS7 5OS8 5OSL 5OSP 5OSR 5OSU 5OSZ 5OT5 5OT6 5OTD 5OTH 5OTI 5OTL 5OTO 5OTP 5OTQ 5OTR 5OTS 5OTY 5OTZ 5OUE 5OUL 5OUM 5OUU 5OWH 5OWL 5OYF 5T1H 5VIE 5VIF 5ZN0 5ZN1 5ZN2 5ZN3 5ZN4 5ZN5 6A1C 6E37 6EHK 6EHU 6EII 6FVF 6FVG 6GIH 6GMD 6HBN 6HME 6HNW 6HNY 6HOP 6HOQ 6HOR 6HOT 6HOU 6JWA 6L1Z 6L21 6L22 6L24 6Q38 6Q4Q 6QY7 6RB1 6RCB 6RCM 6RFE 6RFF 6SPW 6SPX 6TEI 6TLL 6TLO 6TLP 6TLR 6TLS 6TLU 6TLV 6TLW 6YPG 6YPH 6YPJ 6YPK 6YPN 6YUL 6YUM 6Z83 6Z84 7A49 7A4B 7A4C 7B8H 7B8I
Enriched GO Terms of Interacting Partners?
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