MAL and CD3G

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MAL	CD3G
Description		mal, T cell differentiation protein	CD3g molecule
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Integral Component Of Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Membrane Raft	Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Alpha-beta T Cell Receptor Complex
	Molecular Function	Protein Binding Lipid Binding Peptidase Activator Activity Involved In Apoptotic Process Structural Constituent Of Myelin Sheath	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Complex Adaptor Activity T Cell Receptor Binding Identical Protein Binding
	Biological Process	Membrane Raft Polarization Apoptotic Process Central Nervous System Development Cell Differentiation Myelination Apical Protein Localization	Adaptive Immune Response Establishment Or Maintenance Of Cell Polarity Cell Surface Receptor Signaling Pathway Protein Transport T Cell Activation Positive Thymic T Cell Selection Protein-containing Complex Assembly Regulation Of Lymphocyte Apoptotic Process
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis PD-1 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis
Drugs			Muromonab
Diseases
GWAS
Interacting Genes		81 interacting genes: AMHR2 AQP6 BCL2L13 BTN2A1 CALN1 CD300LG CD3G CD40 CD53 CD69 CLDN14 CLDN20 CLDN7 CLDN9 CLEC4C CLSTN3 CPLX4 CREB3L1 CXADR DAGLA EDA EMP1 EVI2A FAM209A FCRL2 FIBCD1 FNDC9 GJA8 GJB1 GPR152 GRAMD1A GSG1L HIBADH IL10RA IL20RB JAML KCNA1 KCNA10 KCNMB4 KLRC1 LDLRAD1 LMAN2L LMNA LRRC25 LRTM1 LSMEM1 MC4R MS4A4A MYD88 NCAPH2 NKAIN4 NPDC1 OPRM1 PERP PLA2G10 PRRT1 PTPRN RAMP1 SDC4 SGCB SHISA3 SHISA4 SLC10A1 SLC35C2 SMIM3 SPINT1 STX1A SYNDIG1 TEX29 TIGIT TM4SF18 TMEM106C TMEM174 TMEM207 TMEM213 TMEM248 TMEM30A TMEM52B TNFSF14 TSPO2 USP7	15 interacting genes: CD3D CD3E DRD2 EMP1 KTN1 LAT MAL PMP22 TMEM19 TMEM203 TMEM262 TMEM54 TRA TRB TRD
Entrez ID		4118	917
HPRD ID		01789	07037
Ensembl ID		ENSG00000172005	ENSG00000160654
Uniprot IDs		A0A024RE19 P21145	B0YIY5 P09693
PDB IDs			1SY6 6JXR
Enriched GO Terms of Interacting Partners?
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