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MIR34A and EIF2AK2
Number of citations of the paper that reports this interaction (PubMedID
28431233
)
92
Data Source:
BioGRID
(unspecified method)
MIR34A
EIF2AK2
Description
microRNA 34a
eukaryotic translation initiation factor 2 alpha kinase 2
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Exosome
Extracellular Vesicle
Nucleus
Cytoplasm
Cytosol
Ribosome
Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
MRNA 3'-UTR Binding
MRNA Binding Involved In Posttranscriptional Gene Silencing
RNA Binding
Double-stranded RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Eukaryotic Translation Initiation Factor 2alpha Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Protein Phosphatase Regulator Activity
Identical Protein Binding
Protein Serine Kinase Activity
Biological Process
Cellular Response To DNA Damage Stimulus
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Lipid Storage
Positive Regulation Of Cell Death
Negative Regulation Of Angiogenesis
Negative Regulation Of Cell Migration
Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Transmembrane Transport
Gene Silencing By MiRNA
Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
Cholesterol Homeostasis
Response To Axon Injury
Negative Regulation Of B Cell Receptor Signaling Pathway
Positive Regulation Of Smooth Muscle Cell Differentiation
Regulation Of Cell Cycle
Negative Regulation Of Protein Kinase B Signaling
Negative Regulation Of Vascular Wound Healing
Triglyceride Homeostasis
Cellular Response To Hypoxia
Negative Regulation Of Smooth Muscle Cell Chemotaxis
Negative Regulation Of Protein Serine/threonine Kinase Activity
Negative Regulation Of Calcium Ion Import
Positive Regulation Of Blood Vessel Endothelial Cell Differentiation
Negative Regulation Of Lipid Transporter Activity
Negative Regulation Of Amyloid-beta Clearance
Positive Regulation Of Protein Acetylation
Negative Regulation Of Intracellular Signal Transduction
Negative Regulation Of Sprouting Angiogenesis
Negative Regulation Of Vascular Endothelial Growth Factor Production
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Positive Regulation Of Connective Tissue Replacement
Positive Regulation Of Hydrogen Peroxide-induced Cell Death
Negative Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Cellular Senescence
Positive Regulation Of Cytokine Production
Translation
Protein Phosphorylation
Negative Regulation Of Cell Population Proliferation
Response To Virus
Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation
Negative Regulation Of Translation
Peptidyl-tyrosine Phosphorylation
Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Chemokine Production
Positive Regulation Of Stress-activated MAPK Cascade
Negative Regulation Of Osteoblast Proliferation
Cellular Response To Amino Acid Starvation
Response To Interferon-alpha
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Protein Autophosphorylation
Regulation Of Catalytic Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of NIK/NF-kappaB Signaling
Regulation Of Hematopoietic Progenitor Cell Differentiation
Regulation Of Hematopoietic Stem Cell Proliferation
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
ISG15 antiviral mechanism
Inhibition of PKR
Drugs
Fostamatinib
Diseases
GWAS
Height (
31562340
)
Lean body mass (
28552196
)
Glucose homeostasis traits (
25524916
)
Platelet count (
32888494
)
Interacting Genes
102 interacting genes:
ADARB1
AIMP1
AIMP2
APOBEC3B
AQR
ATXN2L
C1QBP
CDC5L
CELF1
CPSF1
CPSF6
DARS1
DDX1
DDX21
DDX3X
DDX3Y
DHX36
DHX37
EDC4
EIF2AK2
EPRS1
ESRP1
FAM98A
FAM98B
FIP1L1
FUS
G3BP2
HARS2
HNRNPA0
HNRNPA1
HNRNPA2B1
HNRNPA3
HNRNPF
HNRNPH1
HNRNPH2
HNRNPH3
HNRNPK
HNRNPL
HNRNPM
HNRNPR
IARS1
IGF2BP1
IGF2BP2
IGF2BP3
KARS1
KNOP1
LARP7
LARS1
LIN28A
LIN28B
LRPPRC
MARS1
MATR3
MSI2
MYEF2
NOL6
NONO
NUDT16L1
NUDT21
NUFIP2
PDCD11
PGAM5
PLOD1
PRMT1
PTBP1
PTBP3
PUF60
PUM1
PURA
QARS1
RARS1
RBFOX2
RBM12B
RBM14
RBM4
RTCB
SART3
SF1
SF3A1
SF3A3
SF3B1
SF3B2
SF3B3
SF3B4
SFPQ
SPOUT1
STRBP
SYMPK
SYNCRIP
TAF15
TIAL1
TRA2A
TRA2B
TRIM25
TRMT1L
U2SURP
UPF1
UTP20
YBX1
YBX2
YBX3
ZNF346
125 interacting genes:
ADARB1
CASP3
CASP7
CASP8
CDC42
CHUK
DHX58
DHX9
DICER1
DNAJC3
EDC4
EIF2A
EIF2S1
EIF6
ELF2
FTSJ3
H2AC20
H2AC4
HSP90AA1
HSPA1A
IKBKB
IL7R
ILF2
ILF3
JAK1
MAP3K5
MAP3K7
METAP2
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
MOV10
NFKBIA
NPM1
OGT
PDGFRB
PPP1CA
PPP1CC
PPP2R5A
PRKRA
PRKRIP1
PTGES3
RAC1
STAT1
STAT3
STRBP
SUMO1
TAB2
TARBP2
THAP12
TIRAP
TOLLIP
TP53
TYK2
UBE2I
ZNF346
Entrez ID
407040
5610
HPRD ID
01468
Ensembl ID
ENSG00000284357
ENSG00000055332
Uniprot IDs
P19525
Q8IW76
PDB IDs
1QU6
2A19
2A1A
3UIU
6D3K
6D3L
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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