MIR15A and DDX3X

Number of citations of the paper that reports this interaction (PubMedID 28431233)
92

Data Source:
BioGRID (unspecified method)

		MIR15A	DDX3X
Description		microRNA 15a	DEAD-box helicase 3 X-linked
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Extracellular Exosome Extracellular Vesicle	Extracellular Region Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Cytoplasmic Stress Granule Lamellipodium Cell Leading Edge Secretory Granule Lumen P Granule Extracellular Exosome NLRP3 Inflammasome Complex Ficolin-1-rich Granule Lumen
	Molecular Function	MRNA 3'-UTR Binding MRNA Binding Involved In Posttranscriptional Gene Silencing	DNA Binding DNA Helicase Activity RNA Binding RNA Helicase Activity MRNA Binding GTPase Activity Protein Binding ATP Binding Transcription Factor Binding Poly(A) Binding Eukaryotic Initiation Factor 4E Binding ATP Hydrolysis Activity Nucleoside-triphosphatase Activity Translation Initiation Factor Binding RNA Strand Annealing Activity RNA Stem-loop Binding Gamma-tubulin Binding Ribosomal Small Subunit Binding CTPase Activity Protein Serine/threonine Kinase Activator Activity Cadherin Binding MRNA 5'-UTR Binding
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Angiogenesis Negative Regulation Of NF-kappaB Transcription Factor Activity Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Positive Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Inflammatory Response Cellular Response To Glucose Stimulus Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Cell Chemotaxis To Fibroblast Growth Factor Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Translational Initiation Chromosome Segregation Gamete Generation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Virus RNA Secondary Structure Unwinding Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Translation Cell Differentiation Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Primary MiRNA Processing Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Autophosphorylation DNA Duplex Unwinding Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Stress Granule Assembly Positive Regulation Of Toll-like Receptor 7 Signaling Pathway Positive Regulation Of Toll-like Receptor 8 Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Mature Ribosome Assembly Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Translational Initiation Lipid Homeostasis Cellular Response To Arsenic-containing Substance Cellular Response To Osmotic Stress Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Canonical Wnt Signaling Pathway Intrinsic Apoptotic Signaling Pathway Cellular Response To Virus Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein Acetylation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein K63-linked Ubiquitination Protein Localization To Cytoplasmic Stress Granule Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS			Refractive error ( 32231278)
Interacting Genes		73 interacting genes: AIMP1 AIMP2 C1QBP CPSF1 DARS1 DDX1 DDX21 DDX3X DDX49 DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 FAM98A FUS HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT21 PDCD11 PGAM5 PLOD1 PRMT1 PTBP1 PUF60 QARS1 RARS1 RBM14 RTCA RTCB SF3A1 SF3B1 SF3B2 SF3B3 SFPQ SPOUT1 SYNCRIP TAF15 TRA2A TRA2B TRIM71 TRMT10C UPF1 UTP20 YBX1 YBX3 ZNF346	98 interacting genes: APBB1 CETN2 CSNK2A1 DUX4 ESR1 GABRE HNF4A IKBKE IL7R LINC01232 LINC01554 MAVS MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NEDD4 NFKB2 NUP62 OGT PIN1 RABEP1 SREK1 SRPK2 SUMO2 TBC1D25 WBP4 XPO1 YWHAQ ZNF512B
Entrez ID		406948	1654
HPRD ID			02154
Ensembl ID		ENSG00000283785	ENSG00000215301
Uniprot IDs			A0A2R8Y7T2 A0A2R8YFS5 O00571
PDB IDs			2I4I 2JGN 3JRV 4O2C 4O2E 4O2F 4PX9 4PXA 5E7I 5E7J 5E7M 6CZ5 6O5F
Enriched GO Terms of Interacting Partners?
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