LTK and DUSP6

Number of citations of the paper that reports this interaction (PubMedID 28065597)
37

Data Source:
BioGRID (two hybrid)

		LTK	DUSP6
Description		leukocyte receptor tyrosine kinase	dual specificity phosphatase 6
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Receptor Complex	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Cell Population Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Cellular Response To Retinoic Acid	MAPK Cascade Negative Regulation Of Protein Phosphorylation Response To Xenobiotic Stimulus Response To Organic Cyclic Compound Cell Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Response To Nitrosative Stress Regulation Of Heart Growth Negative Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor
Pathways			RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway Signaling by MAPK mutants
Drugs		Fostamatinib
Diseases
GWAS		High density lipoprotein cholesterol levels ( 31928498) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lymphocyte percentage of white cells ( 32888494) Type 2 diabetes ( 30297969) Urinary albumin excretion (no hypertensive medication) ( 30220432)	Age at first sexual intercourse ( 34211149) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 29325848 30478444) Night sleep phenotypes ( 27126917)
Interacting Genes		6 interacting genes: CBL DUSP6 MTMR14 PIK3C2B PTPN1 SHC1	20 interacting genes: AATK CHRNE ERBB4 GABRA5 GLA IGF1 LMTK2 LTK MAPK1 MAPK3 MDFI NFYB NTN4 ROR2 SRPK1 TEX11 TPO TTN TXK ZNF212
Entrez ID		4058	1848
HPRD ID		01052	04124
Ensembl ID		ENSG00000062524	ENSG00000139318
Uniprot IDs		P29376	A0A024RBC1 Q16828 Q53GP9
PDB IDs			1HZM 1MKP
Enriched GO Terms of Interacting Partners?
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