GTF2H5 and GTF2H2

Number of citations of the paper that reports this interaction (PubMedID 15220921)
100

Data Source:
HPRD (in vivo)

		GTF2H5	GTF2H2
Description		general transcription factor IIH subunit 5	general transcription factor IIH subunit 2
Image
GO Annotations	Cellular Component	Transcription Factor TFIIH Core Complex Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Nucleolus Cytoplasm	Core TFIIH Complex Portion Of Holo TFIIH Complex Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Nuclear Speck
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding RNA Polymerase II General Transcription Initiation Factor Activity Protein N-terminus Binding
	Biological Process	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Assembly Transcription Elongation From RNA Polymerase I Promoter Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Phosphorylation Of RNA Polymerase II C-terminal Domain Cellular Response To Gamma Radiation	G Protein-coupled Receptor Internalization Nucleotide-excision Repair Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Response To UV Positive Regulation Of DNA Helicase Activity
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS		Lipoprotein (a) levels ( 26377243) Plasma anti-thyroglobulin levels ( 29678681) Systemic sclerosis ( 29293537)
Interacting Genes		8 interacting genes: ANKRD29 CDK7 ERCC3 GSC2 GTF2E1 GTF2H2 INCA1 NGRN	16 interacting genes: AR CDK7 CWC27 CYP26B1 DNMT3L ERCC2 ERCC3 ERCC8 ERRFI1 GTF2E1 GTF2H1 GTF2H3 GTF2H4 GTF2H5 MNAT1 SRA1
Entrez ID		404672	2966
HPRD ID		10581	03450
Ensembl ID		ENSG00000272047	ENSG00000145736
Uniprot IDs		Q6ZYL4	Q13888
PDB IDs		1YDL 2JNJ 5IVW 5IY6 5IY7 5IY8 5IY9 5OF4 6NMI 6O9L 6O9M 6RO4	1Z60 5IVW 5IY6 5IY7 5IY8 5IY9 5O85 5OF4 6NMI 6O9L 6O9M 6RO4
Enriched GO Terms of Interacting Partners?
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