LPL and UBE2Z

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LPL	UBE2Z
Description		lipoprotein lipase	ubiquitin conjugating enzyme E2 Z
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Very-low-density Lipoprotein Particle Chylomicron	Nucleus Nucleoplasm Cytosol
	Molecular Function	Lipoprotein Lipase Activity Phospholipase Activity Triglyceride Lipase Activity Signaling Receptor Binding Calcium Ion Binding Protein Binding Heparin Binding Phospholipase A1 Activity Lipase Activity Triglyceride Binding Apolipoprotein Binding Protein Homodimerization Activity Heparan Sulfate Proteoglycan Binding Protein-membrane Adaptor Activity Phosphatidylserine 1-acylhydrolase Activity 1-acyl-2-lysophosphatidylserine Acylhydrolase Activity Lipoprotein Particle Binding	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Triglyceride Metabolic Process Phospholipid Metabolic Process Response To Cold Response To Xenobiotic Stimulus Response To Glucose Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Positive Regulation Of Cholesterol Storage Positive Regulation Of Sequestering Of Triglyceride Lipid Catabolic Process Triglyceride Biosynthetic Process Triglyceride Catabolic Process Cellular Response To Nutrient Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Cholesterol Homeostasis Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Inflammatory Response Low-density Lipoprotein Particle Mediated Signaling Triglyceride Homeostasis Cellular Response To Fatty Acid Negative Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Negative Regulation Of Endopeptidase Activity Protein Ubiquitination Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process
Pathways		Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling Retinoid metabolism and transport	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Tyloxapol Omega-3-carboxylic acids Glycyrrhizic acid
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549 33730874) Apolipoprotein B levels ( 32203549) Body mass index (adult) ( 28430825) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cardiovascular disease risk factors ( 21943158) Cholesterol ( 31902109) Cholesterol efflux capacity ( 30369316) Coronary artery disease ( 32469254 29212778 24262325 30104761 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diffusing capacity of carbon monoxide ( 30694715) Eosinophil counts ( 32888494) Fasting triglyceride levels ( 32603185) Gut microbiota (beta diversity) ( 27723756) HDL cholesterol ( 23726366 24097068 20031538 21909109 28270201 24507774 18193043 18193044 20864672 26160806 19060906 19060911 21347282 25961943 26780889 20686565 26582766) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) HDL cholesterol levels ( 32203549 31694877 28334899 26763881 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) HDL levels x fish oil supplementation interaction (2df) ( 33760818) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 30718733 32902719 30911093 29403010 33339817 29615537 28548082) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hyperactive-impulsive symptoms ( 18821565) Hypertriglyceridemia ( 23505323 20657596) Lipid metabolism phenotypes ( 22286219 19936222) Lipid traits ( 24386095 24023261) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Low density lipoprotein cholesterol levels ( 32902719 32154731) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (antithrombotic agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527 30382898 21386085 20694148 31589552) Metabolic syndrome (bivariate traits) ( 21386085) Metabolic syndrome (multivariate analysis) ( 29632305) Metabolic traits ( 19060910) Metabolically unhealthy in normal weight ( 33500527) Metabolically unhealthy in obesity ( 33500527) Metabolite levels ( 22916037) Metabolite levels (lipoprotein measures) ( 27005778) Myocardial infarction ( 33532862) NHDL cholesterol levels ( 32902719) Peripheral artery disease ( 31285632) Persistent hepatitis B virus infection ( 27244555) Platelet distribution width ( 32888494) Postprandial triglyceride levels ( 32603185) Pulse pressure ( 27841878) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Systolic blood pressure ( 27841878) Total cholesterol levels ( 32902719) Total triglycerides levels ( 29084231 26690388) Triacylglyceride levels ( 31551469) Triglyceride levels ( 30718733 32203549 28334899 26763881 32154731 30911093 29403010 33339817 29615537 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels in HIV infection ( 33109212) Triglyceride levels in small VLDL ( 29084231) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglyceride to HDL cholesterol ratio ( 28046027) Triglycerides ( 23726366 24097068 21909109 24507774 18193043 18193044 18193046 20864672 26160806 19060906 19060911 24886709 22171074 20139978 17463246 25961943 20686565 26582766) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Type 2 diabetes ( 30054458 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382) Waist circumference and related phenotypes ( 18454146)	Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Myocardial infarction ( 26343387) Platelet count ( 32888494) Plateletcrit ( 32888494) Type 2 diabetes ( 30054458 29358691)
Interacting Genes		17 interacting genes: APOC2 APP ASCC2 CALR CCND1 CEP126 CETP COPS6 EMD LRP1 LRP2 LUC7L2 PTPN4 RPL18A TSC22D2 UBE2Z VLDLR	39 interacting genes: AK8 BMPR1B CCT3 DZIP3 GORASP2 HLTF HMBOX1 INCA1 LNX2 LPL MDM2 OTUB1 PLEKHA6 PLEKHF2 PPP1CA PRKN RAPSN REL RNF103 RNF130 RNF139 RNF144B RNF150 RNF166 RNF41 RNF5 SMAD1 SMAD4 SRA1 SYVN1 TGFBR1 TRAIP TRIM27 TRIM3 TRIM46 TRIM65 UBA1 UBA6 UBD
Entrez ID		4023	65264
HPRD ID		01999	08589
Ensembl ID		ENSG00000175445	ENSG00000159202
Uniprot IDs		A0A1B1RVA9 P06858	Q9H832
PDB IDs		6E7K 6OAU 6OAZ 6OB0 6WN4	5A4P
Enriched GO Terms of Interacting Partners?
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