LIF and NCALD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LIF	NCALD
Description		LIF interleukin 6 family cytokine	neurocalcin delta
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol	Cytosol Clathrin Coat Of Trans-Golgi Network Vesicle
	Molecular Function	Signaling Receptor Binding Cytokine Activity Leukemia Inhibitory Factor Receptor Binding Protein Binding Growth Factor Activity	Actin Binding Calcium Ion Binding Protein Binding Tubulin Binding Clathrin Binding Alpha-tubulin Binding
	Biological Process	Blood Vessel Remodeling Immune Response Tyrosine Phosphorylation Of STAT Protein Multicellular Organism Development Embryo Implantation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Stem Cell Population Maintenance Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Positive Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAPK Cascade Regulation Of Cell Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Decidualization Negative Regulation Of Hormone Secretion Lung Alveolus Development Muscle Organ Morphogenesis Neuron Development Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Stem Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Lung Vasculature Development Lung Lobe Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Histone H3-K27 Acetylation Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	Regulation Of Systemic Arterial Blood Pressure Vesicle-mediated Transport Calcium-mediated Signaling
Pathways		Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions	Activation of Ca-permeable Kainate Receptor
Drugs
Diseases
GWAS		Delirium ( 29631748) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 23128233) Inflammatory bowel disease (early onset) ( 19915574) Nephropathy ( 21399633) Tonsillectomy ( 27941131)	Age-related hearing impairment ( 24939585) Cerebral amyloid angiopathy ( 25188341) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Coffee consumption ( 21876539) Cognitive performance ( 20125193) Coronary artery disease ( 33020668) Gait speed in old age ( 28077804) LDL peak particle diameter (total fat intake interaction) ( 26112879) Medication use (beta blocking agents) ( 31015401) Microalbuminuria ( 26631737) Perceived sweetness of sucrose ( 31005972) Red cell distribution width ( 32888494) Systolic blood pressure ( 30224653)
Interacting Genes		7 interacting genes: HPGDS IL6ST KRT31 KRTAP12-3 LIFR NCALD NF2	33 interacting genes: ACTB ANOS1 APOL3 C19orf44 C1QTNF2 CLTC CREM DTX2 FGF6 FZD7 GOLGA7 GPX7 IGFBP6 KRT6A LCE2D LIF LITAF LY6G6D MEOX2 MICOS10-NBL1 MIEF2 MLLT10 MYDGF NBL1 PLAAT2 PNP SBSN SPRED1 SRGN TMEM14B TPSG1 TUBA4A TUBB
Entrez ID		3976	83988
HPRD ID		08869	09466
Ensembl ID		ENSG00000128342	ENSG00000104490
Uniprot IDs		P15018	B2RB70 P61601
PDB IDs		1EMR 1PVH 2Q7N
Enriched GO Terms of Interacting Partners?
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