CLEC17A and PELI2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CLEC17A	PELI2
Description		C-type lectin domain containing 17A	pellino E3 ubiquitin protein ligase family member 2
Image		No pdb structure
GO Annotations	Cellular Component	Cell Surface Integral Component Of Membrane	Cytosol
	Molecular Function	Protein Binding Mannose Binding Identical Protein Binding Fucose Binding Metal Ion Binding	Protein Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process		Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Toll Signaling Pathway Regulation Of Toll Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade
Pathways			Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Iris color (L* coordinate) ( 30895295) Low density lipoprotein cholesterol levels ( 33339817) Response to antidepressants (symptom improvement) ( 29160301) Total cholesterol levels ( 33339817)	Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Body mass index (smoking years interaction) ( 23192594) Body mass index (ever vs never smoking interaction) ( 23192594) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) End-stage kidney disease ( 31178898) Height ( 25133637) Nickel levels ( 26025379) Telomere length ( 21460395)
Interacting Genes		21 interacting genes: ASGR2 ATP6V0C CLDN8 CTXN3 CXCL9 FAM3C GPR152 IGFBP5 NCK2 NINJ2 OLFM4 PELI1 PELI2 RPRM SEC23A SMIM3 TM4SF4 TMEM140 TMEM201 TMEM218 UPK2	35 interacting genes: BCL10 CLEC17A CREB3L3 DEAF1 ERO1A FN1 FRYL HNRNPK HYAL2 IRAK1 IRAK2 IRAK4 LAMC3 LTBP3 LZTFL1 MDFI MEOX1 MYD88 NUP62 OR7D2 PCGF2 PICALM RABEP1 REL RMDN3 SEPTIN3 SP4 SRPK1 THAP7 TIMM9 TMEM79 TP53 TP63 TRIM32 UBQLN4
Entrez ID		388512	57161
HPRD ID		16993	17835
Ensembl ID		ENSG00000187912	ENSG00000139946
Uniprot IDs		Q6ZS10	Q9H716 Q9HAT8
PDB IDs			3EGA 3EGB
Enriched GO Terms of Interacting Partners?
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